Laboratory and clinical studies on cefpirome

Yoshio Sawae, Toshiyuki Ishimaru, Koji Takagi, Nobuyuki Shimono

研究成果: Contribution to journalArticle査読

抄録

We performed laboratory and clinical studies on cefpirome (CPR), a new injectable cephem antibiotic, with the following results. 1. Antibacterial activity The MICs of CPR against various clinical isolates were determined with an inoculum size of 106 cells/ml. The MIC80 was 3.13 µg/ml for Staphylococcus aureus, 25 µg/ml for Enterococcus faecalis, 0.10 µg/ml for Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes and Proteus mirabilis, 0.39 µg/ml for Serratia marcescens, 0.78 µg/ml for Enterobacter cloacae and Proteus vulgaris, 1.56 µg/ml for Citrobacter spp. and 50 µg/ml for Pseudomonas aeruginosa. It was also found that, compared with the control drugs, cefotaxime, ceftazidime and cefoperazone, CPR showed superior activity against many kinds of bacteria. 2. Clinical results A total of 11 patients (5 with pneumonia. 2 with acute bronchitis. 1 with chronic bronchitis, 1 with pyelonephritis and 1 with fever of unknown origin) were treated with CPR at a daily dose of 2 g for 5-20 days. Clinical response was excellent in 1 patient, good in 7. fair in 2 and poor in 1. No side-effects were observed, but eosinophilia was noted in three patients. From the above results, we consider that CPR is one of the most useful antibiotics for the treatment of infectious diseases.

本文言語英語
ページ(範囲)192-197
ページ数6
ジャーナルChemotherapy
39
DOI
出版ステータス出版済み - 1991

All Science Journal Classification (ASJC) codes

  • 薬理学(医学)
  • 感染症
  • 薬理学
  • 創薬
  • 腫瘍学

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