Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

Kiyoharu Ito, Yoshihiro Anada, Motohiro Tani, Mika Ikeda, Takamitsu Sano, Akio Kihara, Yasuyuki Igarashi

研究成果: ジャーナルへの寄稿学術誌査読

152 被引用数 (Scopus)

抄録

Platelets are known to store a large amount of the bioactive lipid molecule sphingosine 1-phosphate (S1P) and to release it into the plasma in a stimuli-dependent manner. Erythrocytes can also release S1P, independently from any stimuli. We measured the S1P and sphingosine (Sph) levels in erythrocytes by HPLC and found that the contribution of erythrocyte S1P to whole blood S1P levels is actually higher than that of platelets. In vitro assays demonstrated that erythrocytes possess much weaker Sph kinase activity compared to platelets but lack the S1P-degrading activities of either S1P lyase or S1P phosphohydrolase. This combination may enable erythrocytes to maintain a high S1P content relative to Sph. The absence of both S1P-degrading enzymes has not been reported for other cell types. Thus, erythrocytes may be specialized cells for storing and supplying plasma S1P.

本文言語英語
ページ(範囲)212-217
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
357
1
DOI
出版ステータス出版済み - 5月 25 2007
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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