Lacticin Q-mediated selective toxicity depending on physicochemical features of membrane components

Fuminori Yoneyama, Kanako Ohno, Yuichi Imura, Mengqi Li, Takeshi Zendo, Jiro Nakayama, Katsumi Matsuzaki, Kenji Sonomoto

研究成果: Contribution to journalArticle査読

18 被引用数 (Scopus)

抄録

Lacticin Q, a lactococcal pore-forming bacteriocin, shows activity toward Gram-positive bacteria but not Gram-negative bacteria. Lacticin Q did not induce permeability of the outer membrane of Gram-negative bacteria. Experiments using model membranes containing outer membrane components suggested that lacticin Q binds to the outer membrane of Gram-negative bacteria but is unable to penetrate it. The lack of activity of lacticin Q was attributed to physicochemical features of the outer membrane components.

本文言語英語
ページ(範囲)2446-2450
ページ数5
ジャーナルAntimicrobial Agents and Chemotherapy
55
5
DOI
出版ステータス出版済み - 5 2011

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)
  • 感染症

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