Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

Teruaki Hasegawa; Mariko Umeda; Takahiro Matsumoto; Munenori Numata; Masami Mizu; Kazuya Koumoto; Kazuo Sakurai; Seiji Shinkai

doi:10.1039/b313426a

Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

Teruaki Hasegawa, Mariko Umeda, Takahiro Matsumoto, Munenori Numata, Masami Mizu, Kazuya Koumoto, Kazuo Sakurai, Seiji Shinkai

高等研究院

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

22 被引用数 (Scopus)

抄録

A schizophyllan (β-1,3-glucan) derivative carrying lactose-appendages prepared by reductive amination can form stable macromolecular complexes with polynucleotides, shows excellent affinity with a lactose-binding lectin, and effectively mediates gene transfection into hepatocytes.

本文言語	英語
ページ（範囲）	382-383
ページ数	2
ジャーナル	Chemical Communications
巻	4
号	4
DOI	https://doi.org/10.1039/b313426a
出版ステータス	出版済み - 1月 1 2004

!!!All Science Journal Classification (ASJC) codes

触媒
電子材料、光学材料、および磁性材料
セラミックおよび複合材料
化学 (全般)
表面、皮膜および薄膜
金属および合金
材料化学

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author = "Teruaki Hasegawa and Mariko Umeda and Takahiro Matsumoto and Munenori Numata and Masami Mizu and Kazuya Koumoto and Kazuo Sakurai and Seiji Shinkai",

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AU - Hasegawa, Teruaki

AU - Umeda, Mariko

AU - Matsumoto, Takahiro

AU - Numata, Munenori

AU - Mizu, Masami

AU - Koumoto, Kazuya

AU - Sakurai, Kazuo

AU - Shinkai, Seiji

PY - 2004/1/1

Y1 - 2004/1/1

N2 - A schizophyllan (β-1,3-glucan) derivative carrying lactose-appendages prepared by reductive amination can form stable macromolecular complexes with polynucleotides, shows excellent affinity with a lactose-binding lectin, and effectively mediates gene transfection into hepatocytes.

AB - A schizophyllan (β-1,3-glucan) derivative carrying lactose-appendages prepared by reductive amination can form stable macromolecular complexes with polynucleotides, shows excellent affinity with a lactose-binding lectin, and effectively mediates gene transfection into hepatocytes.

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Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

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!!!All Science Journal Classification (ASJC) codes

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