TY - JOUR
T1 - Large cell neuroendocrine carcinoma of the mediastinum with α-fetoprotein production
AU - Takezawa, Ken
AU - Okamoto, Isamu
AU - Fukuoka, Junya
AU - Tanaka, Kaoru
AU - Kaneda, Hiroyasu
AU - Uejima, Hisao
AU - Yoon, Hyung Eun
AU - Imakita, Masami
AU - Fukuoka, Masahiro
AU - Nakagawa, Kazuhiko
PY - 2008/2
Y1 - 2008/2
N2 - Large cell neuroendocrine carcinoma (LCNEC) is a relatively new category of pulmonary neuroendocrine tumor. Although it was first detected in the lung, LCNEC has since been found in a variety of extrapulmonary sites. We now describe a patient who was diagnosed with LCNEC originating from the mediastinum, an extremely rare disorder. An increased serum concentration of α-fetoprotein (AFP) in the patient was reduced by chemotherapy in association with tumor shrinkage. Furthermore, the tumor was confirmed immunohistochemically to produce AFP. To our knowledge, this is the first report of a LCNEC that produces AFP.
AB - Large cell neuroendocrine carcinoma (LCNEC) is a relatively new category of pulmonary neuroendocrine tumor. Although it was first detected in the lung, LCNEC has since been found in a variety of extrapulmonary sites. We now describe a patient who was diagnosed with LCNEC originating from the mediastinum, an extremely rare disorder. An increased serum concentration of α-fetoprotein (AFP) in the patient was reduced by chemotherapy in association with tumor shrinkage. Furthermore, the tumor was confirmed immunohistochemically to produce AFP. To our knowledge, this is the first report of a LCNEC that produces AFP.
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U2 - 10.1097/JTO.0b013e3181623359
DO - 10.1097/JTO.0b013e3181623359
M3 - Article
C2 - 18303442
AN - SCOPUS:40049110770
VL - 3
SP - 187
EP - 189
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
SN - 1556-0864
IS - 2
ER -