Larynx-preserving limited resection and free jejunal graft for carcinoma of the cervical esophagus

Hiroshi Miyata, Makoto Yamasaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

抄録

Background: There is no generally accepted treatment strategy for cervical cancer. The aim of this study was to evaluate the safety and efficacy of larynx-preserving limited resection with free jejunal graft for cervical esophageal cancer. Methods: We retrospectively reviewed data of 58 patients with cervical esophageal cancer who underwent limited resection and free jejunal graft with or without laryngeal preservation. Among them, 45 patients received neoadjuvant treatment. Results: Larynx-preserving surgery was conducted in 33 of the 58 patients (56.9 %). A higher proportion of patients who underwent laryngopharyngectomy with cervical esophagectomy (larynx-nonpreserving group) had cT4 tumors than those who underwent larynx-preserving cervical esophagectomy (larynx-preserving group) (72 vs. 12 %). The overall incidence of postoperative complications was similar in the two groups (56 vs. 52 %). The 5-year survival rate was 44.9 % for the entire group. Laryngeal preservation did not reduce overall survival compared with the larynx-nonpreserving operation (5-year survival rate: 57.8 vs. 25.8 %). Multivariate analysis identified the number of metastatic lymph nodes as the only independent prognostic factor. Conclusions: The present study demonstrated that larynx-preserving limited resection with free jejunal graft is feasible. Also, this approach did not worsen the prognosis compared with the larynx-nonpreserving operation. Limited resection with free jejunal graft and laryngeal preservation is a promising treatment strategy for cervical esophageal cancer.

元の言語英語
ページ(範囲)551-557
ページ数7
ジャーナルWorld Journal of Surgery
37
発行部数3
DOI
出版物ステータス出版済み - 3 1 2013
外部発表Yes

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Larynx
Esophagus
Carcinoma
Transplants
Uterine Cervical Neoplasms
Esophageal Neoplasms
Esophagectomy
Survival Rate
Neoadjuvant Therapy
Multivariate Analysis
Lymph Nodes
Safety
Survival
Incidence
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Miyata, H., Yamasaki, M., Takahashi, T., Kurokawa, Y., Nakajima, K., Takiguchi, S., ... Doki, Y. (2013). Larynx-preserving limited resection and free jejunal graft for carcinoma of the cervical esophagus. World Journal of Surgery, 37(3), 551-557. https://doi.org/10.1007/s00268-012-1875-7

Larynx-preserving limited resection and free jejunal graft for carcinoma of the cervical esophagus. / Miyata, Hiroshi; Yamasaki, Makoto; Takahashi, Tsuyoshi; Kurokawa, Yukinori; Nakajima, Kiyokazu; Takiguchi, Shuji; Mori, Masaki; Doki, Yuichiro.

:: World Journal of Surgery, 巻 37, 番号 3, 01.03.2013, p. 551-557.

研究成果: ジャーナルへの寄稿記事

Miyata, H, Yamasaki, M, Takahashi, T, Kurokawa, Y, Nakajima, K, Takiguchi, S, Mori, M & Doki, Y 2013, 'Larynx-preserving limited resection and free jejunal graft for carcinoma of the cervical esophagus', World Journal of Surgery, 巻. 37, 番号 3, pp. 551-557. https://doi.org/10.1007/s00268-012-1875-7
Miyata H, Yamasaki M, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S その他. Larynx-preserving limited resection and free jejunal graft for carcinoma of the cervical esophagus. World Journal of Surgery. 2013 3 1;37(3):551-557. https://doi.org/10.1007/s00268-012-1875-7
Miyata, Hiroshi ; Yamasaki, Makoto ; Takahashi, Tsuyoshi ; Kurokawa, Yukinori ; Nakajima, Kiyokazu ; Takiguchi, Shuji ; Mori, Masaki ; Doki, Yuichiro. / Larynx-preserving limited resection and free jejunal graft for carcinoma of the cervical esophagus. :: World Journal of Surgery. 2013 ; 巻 37, 番号 3. pp. 551-557.
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abstract = "Background: There is no generally accepted treatment strategy for cervical cancer. The aim of this study was to evaluate the safety and efficacy of larynx-preserving limited resection with free jejunal graft for cervical esophageal cancer. Methods: We retrospectively reviewed data of 58 patients with cervical esophageal cancer who underwent limited resection and free jejunal graft with or without laryngeal preservation. Among them, 45 patients received neoadjuvant treatment. Results: Larynx-preserving surgery was conducted in 33 of the 58 patients (56.9 {\%}). A higher proportion of patients who underwent laryngopharyngectomy with cervical esophagectomy (larynx-nonpreserving group) had cT4 tumors than those who underwent larynx-preserving cervical esophagectomy (larynx-preserving group) (72 vs. 12 {\%}). The overall incidence of postoperative complications was similar in the two groups (56 vs. 52 {\%}). The 5-year survival rate was 44.9 {\%} for the entire group. Laryngeal preservation did not reduce overall survival compared with the larynx-nonpreserving operation (5-year survival rate: 57.8 vs. 25.8 {\%}). Multivariate analysis identified the number of metastatic lymph nodes as the only independent prognostic factor. Conclusions: The present study demonstrated that larynx-preserving limited resection with free jejunal graft is feasible. Also, this approach did not worsen the prognosis compared with the larynx-nonpreserving operation. Limited resection with free jejunal graft and laryngeal preservation is a promising treatment strategy for cervical esophageal cancer.",
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AU - Miyata, Hiroshi

AU - Yamasaki, Makoto

AU - Takahashi, Tsuyoshi

AU - Kurokawa, Yukinori

AU - Nakajima, Kiyokazu

AU - Takiguchi, Shuji

AU - Mori, Masaki

AU - Doki, Yuichiro

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N2 - Background: There is no generally accepted treatment strategy for cervical cancer. The aim of this study was to evaluate the safety and efficacy of larynx-preserving limited resection with free jejunal graft for cervical esophageal cancer. Methods: We retrospectively reviewed data of 58 patients with cervical esophageal cancer who underwent limited resection and free jejunal graft with or without laryngeal preservation. Among them, 45 patients received neoadjuvant treatment. Results: Larynx-preserving surgery was conducted in 33 of the 58 patients (56.9 %). A higher proportion of patients who underwent laryngopharyngectomy with cervical esophagectomy (larynx-nonpreserving group) had cT4 tumors than those who underwent larynx-preserving cervical esophagectomy (larynx-preserving group) (72 vs. 12 %). The overall incidence of postoperative complications was similar in the two groups (56 vs. 52 %). The 5-year survival rate was 44.9 % for the entire group. Laryngeal preservation did not reduce overall survival compared with the larynx-nonpreserving operation (5-year survival rate: 57.8 vs. 25.8 %). Multivariate analysis identified the number of metastatic lymph nodes as the only independent prognostic factor. Conclusions: The present study demonstrated that larynx-preserving limited resection with free jejunal graft is feasible. Also, this approach did not worsen the prognosis compared with the larynx-nonpreserving operation. Limited resection with free jejunal graft and laryngeal preservation is a promising treatment strategy for cervical esophageal cancer.

AB - Background: There is no generally accepted treatment strategy for cervical cancer. The aim of this study was to evaluate the safety and efficacy of larynx-preserving limited resection with free jejunal graft for cervical esophageal cancer. Methods: We retrospectively reviewed data of 58 patients with cervical esophageal cancer who underwent limited resection and free jejunal graft with or without laryngeal preservation. Among them, 45 patients received neoadjuvant treatment. Results: Larynx-preserving surgery was conducted in 33 of the 58 patients (56.9 %). A higher proportion of patients who underwent laryngopharyngectomy with cervical esophagectomy (larynx-nonpreserving group) had cT4 tumors than those who underwent larynx-preserving cervical esophagectomy (larynx-preserving group) (72 vs. 12 %). The overall incidence of postoperative complications was similar in the two groups (56 vs. 52 %). The 5-year survival rate was 44.9 % for the entire group. Laryngeal preservation did not reduce overall survival compared with the larynx-nonpreserving operation (5-year survival rate: 57.8 vs. 25.8 %). Multivariate analysis identified the number of metastatic lymph nodes as the only independent prognostic factor. Conclusions: The present study demonstrated that larynx-preserving limited resection with free jejunal graft is feasible. Also, this approach did not worsen the prognosis compared with the larynx-nonpreserving operation. Limited resection with free jejunal graft and laryngeal preservation is a promising treatment strategy for cervical esophageal cancer.

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