Lateral and ventromedial hypothalamic influences on hepatic autonomic nerve activity in the rat

Hironobu Yoshimatsu, Akira Niijima, Yutaka Oomura, Toshihiko Katafuchi

研究成果: Contribution to journalArticle

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Effects of hypothalamic stimulation and lesion on hepatic autonomic nerve activity were investigated in anesthetized rats. Stimulation of the lateral hypothalamic area increased activity of the hepatic vagal nerve and decreased activity of the splanchnic nerve. Lesion of this area produced a rapid and strong reduction of vagal nerve activity and induced either an increase or a decrease of splanchnic nerve activity. In contrast, stimulation of the ventromedial hypothalamic nucleus produced a strong inhibition of vagal nerve activity and facilitation of splanchnic nerve activity. However, lesion of this nucleus facilitated or inhibited activities in both nerve branches. The functional significance of the relationship between the hypothalamus and the hepatic autonomic nerve in regulation of glucose metabolism in the liver are discussed.

元の言語英語
ページ(範囲)239-244
ページ数6
ジャーナルBrain Research Bulletin
21
発行部数2
DOI
出版物ステータス出版済み - 8 1988

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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