Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis

Masaaki Niino, Shinya Sato, Toshiyuki Fukazawa, Satoshi Yoshimura, Shin Hisahara, Takuya Matsushita, Noriko Isobe, Kazuto Yoshida, Hideki Houzen, Yusei Miyazaki, Shun Shimohama, Seiji Kikuchi, Jun-Ichi Kira

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

Background: It is unclear whether the prevalence of oligoclonal IgG bands (OCBs) in multiple sclerosis (MS) is different between northern and southern regions of Asia. Objective: This study aimed to compare the prevalence of OCBs and positive cerebrospinal fluid (CSF) findings between northern and southern regions of Japan and to investigate the association of these CSF findings with HLA-DRB1 alleles. Methods: The study included 180 MS patients from Hokkaido (northern Japan) and 184 patients from Kyushu (southern Japan). The IgG index was defined as increased if it was >0.658. Presence of CSF OCBs and/or increased IgG index was defined as positive CSF findings. Results: Positive CSF findings and OCB positivity were significantly higher in MS patients from Hokkaido than in those from Kyushu (p < 0.0001 for both). Logistic regression analysis revealed that after adjusting for covariates that can be related to abnormal CSF IgG production, the geographic region (Hokkaido) showed odds ratios (ORs) of 4.08 and 2.57, whereas the HLA-DRB104:05 allele showed ORs of 0.36 and 0.30 for positive CSF findings and OCB positivity, respectively. Conclusions: The results indicate that latitude and HLA-DRB1 alleles independently affect the emergence of CSF IgG abnormalities in Japanese patients with MS.

元の言語英語
ページ(範囲)1112-1120
ページ数9
ジャーナルMultiple Sclerosis Journal
21
発行部数9
DOI
出版物ステータス出版済み - 1 1 2015

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Oligoclonal Bands
HLA-DRB1 Chains
Multiple Sclerosis
Cerebrospinal Fluid
Immunoglobulin G
Alleles
Japan
Odds Ratio
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis. / Niino, Masaaki; Sato, Shinya; Fukazawa, Toshiyuki; Yoshimura, Satoshi; Hisahara, Shin; Matsushita, Takuya; Isobe, Noriko; Yoshida, Kazuto; Houzen, Hideki; Miyazaki, Yusei; Shimohama, Shun; Kikuchi, Seiji; Kira, Jun-Ichi.

:: Multiple Sclerosis Journal, 巻 21, 番号 9, 01.01.2015, p. 1112-1120.

研究成果: ジャーナルへの寄稿記事

Niino, M, Sato, S, Fukazawa, T, Yoshimura, S, Hisahara, S, Matsushita, T, Isobe, N, Yoshida, K, Houzen, H, Miyazaki, Y, Shimohama, S, Kikuchi, S & Kira, J-I 2015, 'Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis', Multiple Sclerosis Journal, 巻. 21, 番号 9, pp. 1112-1120. https://doi.org/10.1177/1352458514560924
Niino, Masaaki ; Sato, Shinya ; Fukazawa, Toshiyuki ; Yoshimura, Satoshi ; Hisahara, Shin ; Matsushita, Takuya ; Isobe, Noriko ; Yoshida, Kazuto ; Houzen, Hideki ; Miyazaki, Yusei ; Shimohama, Shun ; Kikuchi, Seiji ; Kira, Jun-Ichi. / Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis. :: Multiple Sclerosis Journal. 2015 ; 巻 21, 番号 9. pp. 1112-1120.
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title = "Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis",
abstract = "Background: It is unclear whether the prevalence of oligoclonal IgG bands (OCBs) in multiple sclerosis (MS) is different between northern and southern regions of Asia. Objective: This study aimed to compare the prevalence of OCBs and positive cerebrospinal fluid (CSF) findings between northern and southern regions of Japan and to investigate the association of these CSF findings with HLA-DRB1 alleles. Methods: The study included 180 MS patients from Hokkaido (northern Japan) and 184 patients from Kyushu (southern Japan). The IgG index was defined as increased if it was >0.658. Presence of CSF OCBs and/or increased IgG index was defined as positive CSF findings. Results: Positive CSF findings and OCB positivity were significantly higher in MS patients from Hokkaido than in those from Kyushu (p < 0.0001 for both). Logistic regression analysis revealed that after adjusting for covariates that can be related to abnormal CSF IgG production, the geographic region (Hokkaido) showed odds ratios (ORs) of 4.08 and 2.57, whereas the HLA-DRB1∗04:05 allele showed ORs of 0.36 and 0.30 for positive CSF findings and OCB positivity, respectively. Conclusions: The results indicate that latitude and HLA-DRB1 alleles independently affect the emergence of CSF IgG abnormalities in Japanese patients with MS.",
author = "Masaaki Niino and Shinya Sato and Toshiyuki Fukazawa and Satoshi Yoshimura and Shin Hisahara and Takuya Matsushita and Noriko Isobe and Kazuto Yoshida and Hideki Houzen and Yusei Miyazaki and Shun Shimohama and Seiji Kikuchi and Jun-Ichi Kira",
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T1 - Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis

AU - Niino, Masaaki

AU - Sato, Shinya

AU - Fukazawa, Toshiyuki

AU - Yoshimura, Satoshi

AU - Hisahara, Shin

AU - Matsushita, Takuya

AU - Isobe, Noriko

AU - Yoshida, Kazuto

AU - Houzen, Hideki

AU - Miyazaki, Yusei

AU - Shimohama, Shun

AU - Kikuchi, Seiji

AU - Kira, Jun-Ichi

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: It is unclear whether the prevalence of oligoclonal IgG bands (OCBs) in multiple sclerosis (MS) is different between northern and southern regions of Asia. Objective: This study aimed to compare the prevalence of OCBs and positive cerebrospinal fluid (CSF) findings between northern and southern regions of Japan and to investigate the association of these CSF findings with HLA-DRB1 alleles. Methods: The study included 180 MS patients from Hokkaido (northern Japan) and 184 patients from Kyushu (southern Japan). The IgG index was defined as increased if it was >0.658. Presence of CSF OCBs and/or increased IgG index was defined as positive CSF findings. Results: Positive CSF findings and OCB positivity were significantly higher in MS patients from Hokkaido than in those from Kyushu (p < 0.0001 for both). Logistic regression analysis revealed that after adjusting for covariates that can be related to abnormal CSF IgG production, the geographic region (Hokkaido) showed odds ratios (ORs) of 4.08 and 2.57, whereas the HLA-DRB1∗04:05 allele showed ORs of 0.36 and 0.30 for positive CSF findings and OCB positivity, respectively. Conclusions: The results indicate that latitude and HLA-DRB1 alleles independently affect the emergence of CSF IgG abnormalities in Japanese patients with MS.

AB - Background: It is unclear whether the prevalence of oligoclonal IgG bands (OCBs) in multiple sclerosis (MS) is different between northern and southern regions of Asia. Objective: This study aimed to compare the prevalence of OCBs and positive cerebrospinal fluid (CSF) findings between northern and southern regions of Japan and to investigate the association of these CSF findings with HLA-DRB1 alleles. Methods: The study included 180 MS patients from Hokkaido (northern Japan) and 184 patients from Kyushu (southern Japan). The IgG index was defined as increased if it was >0.658. Presence of CSF OCBs and/or increased IgG index was defined as positive CSF findings. Results: Positive CSF findings and OCB positivity were significantly higher in MS patients from Hokkaido than in those from Kyushu (p < 0.0001 for both). Logistic regression analysis revealed that after adjusting for covariates that can be related to abnormal CSF IgG production, the geographic region (Hokkaido) showed odds ratios (ORs) of 4.08 and 2.57, whereas the HLA-DRB1∗04:05 allele showed ORs of 0.36 and 0.30 for positive CSF findings and OCB positivity, respectively. Conclusions: The results indicate that latitude and HLA-DRB1 alleles independently affect the emergence of CSF IgG abnormalities in Japanese patients with MS.

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