Leakage mechanism of irinotecan from water-in-oil-in-water (W/O/W) multiple emulsions

Eiichi Toorisaka, Yuko Kokazu, Noriho Kamiya, Masahiro Goto

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

The leakage mechanism of the anticancer drug Irinotecan (CPT-11) from multiple W/O/W emulsions was investigated. The molecular structure of surfactants used for the preparation of the multiple emulsions affected the leakage rate of CPT-11. A sugar-long alkyl chain ester was effective in suppressing the drug release from the emulsions, because the surfactant reduces the mobility of inner aqueous droplets in emulsions. The leakage of drugs was deduced to be caused by the thin lamella membrane formed between the internal and external aqueous phases. The direction of water transportation was also an important factor in the degree of the drug release.

本文言語英語
ページ(範囲)294-298
ページ数5
ジャーナルkagaku kogaku ronbunshu
29
2
DOI
出版ステータス出版済み - 3 2003

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 化学工学(全般)

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