Learning from b12 enzymes: Biomimetic and bioinspired catalysts for eco-friendly organic synthesis

Keishiro Tahara, Ling Pan, Toshikazu Ono, Yoshio Hisaeda

研究成果: Contribution to journalReview article査読

15 被引用数 (Scopus)


Cobalamins (B12) play various important roles in vivo. Most B12-dependent enzymes are divided into three main subfamilies: adenosylcobalamin-dependent isomerases, methylcobalamin-dependent methyltransferases, and dehalogenases. Mimicking these B12 enzyme functions under non-enzymatic conditions offers good understanding of their elaborate reaction mechanisms. Furthermore, bio-inspiration offers a new approach to catalytic design for green and eco-friendly molecular transformations. As part of a study based on vitamin B12 derivatives including heptamethyl cobyrinate perchlorate, we describe biomimetic and bioinspired catalytic reactions with B12 enzyme functions. The reactions are classified according to the corresponding three B12 enzyme subfamilies, with a focus on our recent development on electrochemical and photochemical catalytic systems. Other important reactions are also described, with a focus on radical-involved reactions in terms of organic synthesis.

ジャーナルBeilstein Journal of Organic Chemistry
出版ステータス出版済み - 10 2 2018

All Science Journal Classification (ASJC) codes

  • 有機化学


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