Left atrial assist device to treat patients with heart failure with preserved ejection fraction: Initial in vitro study

Kiyotaka Fukamachi, David J. Horvath, Jamshid H. Karimov, Yuichiro Kado, Takuma Miyamoto, Barry D. Kuban, Randall C. Starling

研究成果: ジャーナルへの寄稿学術誌査読

17 被引用数 (Scopus)

抄録

Objectives: Many patients with heart failure have preserved ejection fraction but also diastolic dysfunction, with no effective therapy. We are developing a new pump (left atrial assist device, LAAD) for implantation at the mitral position to pump blood from the left atrium to sufficiently fill the left ventricle. The purpose of the initial in vitro study was to demonstrate that the LAAD can reduce left atrial pressure (LAP) and increase cardiac output (CO) while maintaining arterial pulsatility and normal aortic valve function using a proof-of-concept device. Methods: The LAAD concept was tested at 3 pump speeds on a pulsatile mock loop with a pneumatic pump that simulated the normal function of the native ventricle as well as 3 levels of diastolic heart failure (DHF 1, 2, and 3) by adjusting the diastolic drive pressure to limit diastolic filling of the ventricle. Results: Without the LAAD, CO and aortic pressure (AoP) decreased dramatically from 3.8 L/min and 100 mm Hg at normal heart condition to 1.2 L/min and 35 mm Hg at DHF 3, respectively. With LAAD support, both CO and AoP recovered to normal heart values at 3200 rpm and surpassed normal heart values at 3800 rpm. Furthermore, with LAAD support, LAP recovered to almost that of the normal heart condition at 3800 rpm. Conclusions: These initial in vitro results support our hypothesis that use of the LAAD increases CO and AoP and decreases LAP under DHF conditions while maintaining arterial pulsatility and full function of the aortic valve.

本文言語英語
ページ(範囲)120-126
ページ数7
ジャーナルJournal of Thoracic and Cardiovascular Surgery
162
1
DOI
出版ステータス出版済み - 7月 2021
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 外科
  • 呼吸器内科
  • 循環器および心血管医学

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