Left frontal glioma induces functional connectivity changes in syntax-related networks

Ryuta Kinno, Shinri Ohta, Yoshihiro Muragaki, Takashi Maruyama, Kuniyoshi L. Sakai

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

Background: A glioma leads to a global loss of functional connectivity among multiple regions. However, the relationships between performance/activation changes and functional connectivity remain unclear. Our previous studies (Brain 137:1193–1212; Brain Lang 110:71–80) have shown that a glioma in the left lateral premotor cortex or the opercular/triangular parts of the left inferior frontal gyrus causes agrammatic comprehension accompanied by abnormal activations in 14 syntax-related regions. We have also confirmed that a glioma in the other left frontal regions does not affect task performances and activation patterns. Results: By a partial correlation method for the time-series functional magnetic resonance imaging data, we analyzed the functional connectivity in 21 patients with a left frontal glioma. We observed that almost all of the functional connectivity exhibited chaotic changes in the agrammatic patients. In contrast, some functional connectivity was preserved in an orderly manner in the patients who showed normal performances and activation patterns. More specifically, these latter patients showed normal connectivity between the left fronto-parietal regions, as well as normal connectivity between the left triangular and orbital parts of the left inferior frontal gyrus. Conclusions: Our results indicate that these pathways are most crucial among the syntax-related networks. Both data from the activation patterns and functional connectivity, which are different in temporal domains, should thus be combined to assess any behavioral deficits associated with brain abnormalities.

元の言語英語
記事番号317
ページ(範囲)1-6
ページ数6
ジャーナルSpringerPlus
4
発行部数1
DOI
出版物ステータス出版済み - 12 1 2015
外部発表Yes

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Glioma
Prefrontal Cortex
Brain
Parietal Lobe
Motor Cortex
Task Performance and Analysis
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • General

これを引用

Left frontal glioma induces functional connectivity changes in syntax-related networks. / Kinno, Ryuta; Ohta, Shinri; Muragaki, Yoshihiro; Maruyama, Takashi; Sakai, Kuniyoshi L.

:: SpringerPlus, 巻 4, 番号 1, 317, 01.12.2015, p. 1-6.

研究成果: ジャーナルへの寄稿記事

Kinno, Ryuta ; Ohta, Shinri ; Muragaki, Yoshihiro ; Maruyama, Takashi ; Sakai, Kuniyoshi L. / Left frontal glioma induces functional connectivity changes in syntax-related networks. :: SpringerPlus. 2015 ; 巻 4, 番号 1. pp. 1-6.
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