Left2right asymmetry defect in the hippocampal circuitry impairs spatial learning and working memory in IV mice

Kazuhiro Goto, Ryo Kurashima, Hayato Gokan, Naomi Inoue, Isao Ito, Shigeru Watanabe

研究成果: ジャーナルへの寄稿記事

31 引用 (Scopus)

抄録

Although left-right (L2R) asymmetry is a fundamental feature of higher-order brain function, little is known about how asymmetry defects of the brain affect animal behavior. Previously, we identified structural and functional asymmetries in the circuitry of the mouse hippocampus resulting from the asymmetrical distribution of NMDA receptor GluR ε2 (NR2B) subunits. We further examined the ε2 asymmetry in the inversus viscerum (iv) mouse, which has randomized laterality of internal organs, and found that the iv mouse hippocampus exhibits right isomerism (bilateral right-sidedness) in the synaptic distribution of the ε2 subunit, irrespective of the laterality of visceral organs. To investigate the effects of hippocampal laterality defects on higher-order brain functions, we examined the capacity of reference and working memories of iv mice using a dry maze and a delayed nonmatching-to-position (DNMTP) task, respectively. The iv mice improved dry maze performance more slowly than control mice during acquisition, whereas the asymptotic level of performance was similar between the two groups. In the DNMTP task, the iv mice showed poorer accuracy than control mice as the retention interval became longer. These results suggest that the L2R asymmetry of hippocampal circuitry is critical for the acquisition of reference memory and the retention of working memory.

元の言語英語
記事番号e15468
ジャーナルPloS one
5
発行部数11
DOI
出版物ステータス出版済み - 12 3 2010

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Short-Term Memory
Brain
learning
Data storage equipment
Defects
mice
N-Methyl-D-Aspartate Receptors
Animals
hippocampus
brain
Hippocampus
Isomerism
Animal Behavior
Spatial Memory
Spatial Learning
isomerization
animal behavior
receptors

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

これを引用

Left2right asymmetry defect in the hippocampal circuitry impairs spatial learning and working memory in IV mice. / Goto, Kazuhiro; Kurashima, Ryo; Gokan, Hayato; Inoue, Naomi; Ito, Isao; Watanabe, Shigeru.

:: PloS one, 巻 5, 番号 11, e15468, 03.12.2010.

研究成果: ジャーナルへの寄稿記事

Goto, Kazuhiro ; Kurashima, Ryo ; Gokan, Hayato ; Inoue, Naomi ; Ito, Isao ; Watanabe, Shigeru. / Left2right asymmetry defect in the hippocampal circuitry impairs spatial learning and working memory in IV mice. :: PloS one. 2010 ; 巻 5, 番号 11.
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