Leptin Receptor

K. Takaya, Y. Ogawa, H. Masuzaki, N. Matsuoka, K. Hosoda, K. Nakao

研究成果: Contribution to journalReview article査読

1 被引用数 (Scopus)

抄録

Leptin is a fat cell-derived satiety factor that regulates food intake and energy expenditure. Its effects are mediated by interactions with the leptin receptor (Ob-R) that is alternatively spliced to encode at least five isoforms(a-e), which are distributed in a wide range of tissues including the hypothalamus. Ob-R is a member of cytokine receptors and involves the JAK-STAT signal transduction system. We found Ob-R mutations in Zucker fatty rats and obese Koletsky rats and demonstrated that Ob-R dysfunction brings around hyperphagia and obesity. However we and others have not found any Ob-R mutation in human obese subjects.

本文言語英語
ページ(範囲)1925-1930
ページ数6
ジャーナルNippon rinsho. Japanese journal of clinical medicine
56
7
出版ステータス出版済み - 1 1 1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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