Lessons from comparative analysis of species-specific imprinted genes

K. Okamura, T. Ito

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

抄録

Genomic imprinting is generally believed to be conserved in all mammals except for egg-laying monotremes, suggesting that it is closely related to placental and fetal growth. As expected, the imprinting status of most imprinted genes is conserved between mouse and human, and some are imprinted even in marsupials. On the other hand, a small number of genes were reported to exhibit species-specific imprinting that is not necessarily accounted for by either the placenta or conflict hypotheses. Since mouse and human represent a single, phylogenetically restricted clade in the mammalian class, a much broader comparison including mammals diverged earlier than rodents is necessary to fully understand the species-specificity and variation in evolution of genomic imprinting. Indeed, comparative analysis of a species-specific imprinted gene Impact using a broader range of mammals led us to propose an alternative dosage control hypothesis for the evolution of genomic imprinting.

元の言語英語
ページ(範囲)159-164
ページ数6
ジャーナルCytogenetic and Genome Research
113
発行部数1-4
DOI
出版物ステータス出版済み - 3 1 2006
外部発表Yes

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Genomic Imprinting
Mammals
Genes
Species Specificity
Marsupialia
Fetal Development
Placenta
Ovum
Rodentia

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

これを引用

Lessons from comparative analysis of species-specific imprinted genes. / Okamura, K.; Ito, T.

:: Cytogenetic and Genome Research, 巻 113, 番号 1-4, 01.03.2006, p. 159-164.

研究成果: ジャーナルへの寄稿記事

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