Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer's Disease

Zhou Wu, Hiroshi Nakanishi

研究成果: Contribution to journalReview article査読

17 被引用数 (Scopus)

抄録

Bone is sensitive to overactive immune responses, which initiate the onset of inflammatory bone disorders, such as rheumatoid arthritis and periodontitis, resulting in a significant systemic inflammatory response. On the other hand, neuroinflammation is strongly implicated in Alzheimer's disease (AD), which can be enhanced by systemic inflammation, such as that due to cardiovascular disease and diabetes. There is growing clinical evidence supporting the concept that rheumatoid arthritis and periodontitis are positively linked to AD, suggesting that inflammatory bone disorders are risk factors for this condition. Recent studies have suggested that leptomeningeal cells play an important role in transducing systemic inflammatory signals to brain-resident microglia. More importantly, senescent-type, but not juvenile-type, microglia provoke neuroinflammation in response to systemic inflammation. Because the prevalence of rheumatoid arthritis and periodontitis increases with age, inflammatory bone disorders may be significant sources of covert systemic inflammation among elderly people. The present review article highlights our current understanding of the link between inflammatory bone disorders and AD with a special focus on microglia aging.

本文言語英語
論文番号471342
ジャーナルJournal of Immunology Research
2015
DOI
出版ステータス出版済み - 2015

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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