Lessons from peroxisome-deficient Chinese hamster ovary (CHO) cell mutants

Yukio Fujiki, Kanji Okumoto, Naohiko Kinoshita, Kamran Ghaedi

研究成果: Contribution to journalReview article査読

43 被引用数 (Scopus)


Cells with a genetic defect affecting a biological activity and/or a cell phenotype are generally called "cell mutants" and are a highly useful tool in genetic, biochemical, as well as cell biological research. To investigate peroxisome biogenesis and human peroxisome biogenesis disorders, more than a dozen complementation groups of Chinese hamster ovary (CHO) cell mutants defective in peroxisome assembly have been successfully isolated and established as a model system. Moreover, successful PEX gene cloning studies by taking advantage of rapid functional complementation assay of CHO cell mutants invaluably contributed to the accomplishment of isolation of pathogenic genes responsible for peroxisome biogenesis diseases. Molecular mechanisms of peroxisome assembly are currently investigated by making use of such mammalian cell mutants.

ジャーナルBiochimica et Biophysica Acta - Molecular Cell Research
出版ステータス出版済み - 12 1 2006

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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