Leucine-rich alpha-2 glycoprotein in the cerebrospinal fluid is a potential inflammatory biomarker for meningitis

Pin Fee Chong, Yasunari Sakai, Hiroyuki Torisu, Tamami Tanaka, Kenji Furuno, Yumi Mizuno, Shoichi Ohga, Toshiro Hara, Ryutaro Kira

研究成果: ジャーナルへの寄稿記事

抄録

Background: Leucine-rich alpha-2 glycoprotein (LRG) is a novel biomarker for inflammatory diseases. We evaluated the levels of LRG, interleukin (IL)-6, and tumor necrosis factor (TNF)-α in the cerebrospinal fluid (CSF) of children with meningitis. Methods: CSF samples from 10 patients with bacterial meningitis (BM) and 10 with aseptic meningitis (AM) were evaluated. Samples from 10 patients with febrile status (FS) were used as controls. LRG levels were measured using a two-site enzyme immunoassay. IL-6 and TNF-α levels were measured using a multiplex bead-based assay. CSF examination of patients with BM at the convalescent stage was also conducted. Results: LRG and TNF-α levels in patients with BM, and IL-6 levels in patients with BM and AM showed significant increase compared with those in FS. Patients with BM at the convalescent stage showed significantly diminished LRG and IL-6 levels. LRG and IL-6 levels in CSF were indicated to be effective predictors for BM (LRG, AUC = 0.91; IL-6, AUC = 0.85). Only LRG levels showed a significant difference between patients with BM and AM (AUC = 0.78, P = 0.034). Conclusions: LRG level could be a sensitive inflammatory biomarker for inflammatory diseases of the central nervous system, comparable with IL-6 level.

元の言語英語
ページ(範囲)51-55
ページ数5
ジャーナルJournal of the Neurological Sciences
392
DOI
出版物ステータス出版済み - 9 15 2018

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Meningitis
Leucine
Bacterial Meningitides
Cerebrospinal Fluid
Glycoproteins
Biomarkers
Interleukin-6
Aseptic Meningitis
Area Under Curve
Tumor Necrosis Factor-alpha
Fever
Central Nervous System Diseases
Immunoenzyme Techniques

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Leucine-rich alpha-2 glycoprotein in the cerebrospinal fluid is a potential inflammatory biomarker for meningitis. / Chong, Pin Fee; Sakai, Yasunari; Torisu, Hiroyuki; Tanaka, Tamami; Furuno, Kenji; Mizuno, Yumi; Ohga, Shoichi; Hara, Toshiro; Kira, Ryutaro.

:: Journal of the Neurological Sciences, 巻 392, 15.09.2018, p. 51-55.

研究成果: ジャーナルへの寄稿記事

Chong, Pin Fee ; Sakai, Yasunari ; Torisu, Hiroyuki ; Tanaka, Tamami ; Furuno, Kenji ; Mizuno, Yumi ; Ohga, Shoichi ; Hara, Toshiro ; Kira, Ryutaro. / Leucine-rich alpha-2 glycoprotein in the cerebrospinal fluid is a potential inflammatory biomarker for meningitis. :: Journal of the Neurological Sciences. 2018 ; 巻 392. pp. 51-55.
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abstract = "Background: Leucine-rich alpha-2 glycoprotein (LRG) is a novel biomarker for inflammatory diseases. We evaluated the levels of LRG, interleukin (IL)-6, and tumor necrosis factor (TNF)-α in the cerebrospinal fluid (CSF) of children with meningitis. Methods: CSF samples from 10 patients with bacterial meningitis (BM) and 10 with aseptic meningitis (AM) were evaluated. Samples from 10 patients with febrile status (FS) were used as controls. LRG levels were measured using a two-site enzyme immunoassay. IL-6 and TNF-α levels were measured using a multiplex bead-based assay. CSF examination of patients with BM at the convalescent stage was also conducted. Results: LRG and TNF-α levels in patients with BM, and IL-6 levels in patients with BM and AM showed significant increase compared with those in FS. Patients with BM at the convalescent stage showed significantly diminished LRG and IL-6 levels. LRG and IL-6 levels in CSF were indicated to be effective predictors for BM (LRG, AUC = 0.91; IL-6, AUC = 0.85). Only LRG levels showed a significant difference between patients with BM and AM (AUC = 0.78, P = 0.034). Conclusions: LRG level could be a sensitive inflammatory biomarker for inflammatory diseases of the central nervous system, comparable with IL-6 level.",
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AU - Chong, Pin Fee

AU - Sakai, Yasunari

AU - Torisu, Hiroyuki

AU - Tanaka, Tamami

AU - Furuno, Kenji

AU - Mizuno, Yumi

AU - Ohga, Shoichi

AU - Hara, Toshiro

AU - Kira, Ryutaro

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