Leukoencephalopathy in HTLV-I-associated myelopathy: MRI and EEG data

Jun ichi Kira, Sei ichiro Minato, Yasuto Itoyama, Ikuo Goto, Motohiro Kato, Kanehiro Hasuo

研究成果: ジャーナルへの寄稿学術誌査読

42 被引用数 (Scopus)


Magnetic resonance imaging (MRI) of the brain and electroencephalography (EEG) were carried out for patients with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM). Nineteen of 22 patients (86%) had abnormalities on brain MRI and/or EEG. Thirteen patients showed high signal intensity lesions scattered in the cerebral white matter, as seen on the T2-weighted MRI images. The lesions were mostly located in the subcortical and deep cerebral white matter and were not contiguous with the lateral ventricles. Patients with abnormalities on the brain MRI had a longer duration of disease and a greater disability than did those without MRI abnormalities. The EEG records showed definite abnormalities in 9, and minor abnormalities in 5. All patients with HAM for more than 5 years showed definite evidence of cerebral involvement. Our findings strongly suggest that a multifocal pathological process over the entire CNS is probably a common occurrence in HAM.

ジャーナルJournal of the Neurological Sciences
出版ステータス出版済み - 11月 1988

!!!All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学


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