Ligand-Mediated Coating of Liposomes with Human Serum Albumin

Hikari Sato, Elnaz Nakhaei, Takahito Kawano, Masaharu Murata, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Coating liposome surfaces with human serum albumin (HSA) can improve the colloidal stability and prevent opsonization. HSA coating via specific binding with alkyl ligands is promising because although the ligand-mediated coating is relatively stable it can spontaneously exchange with fresh HSA. However, to achieve surface coating with HSA, multiple hydrophobic ligands must be exposed to an aqueous medium prior to binding with HSA. This presents a challenge, as hydrophobic ligands tend to be buried in the liposomal membrane. Here we present the first HSA modification of liposome surfaces via alkyl ligands. We found that a relatively short alkyl ligand, or a long alkyl ligand with a terminal carboxylate, could be exposed on the liposome surface without causing aggregation of the liposomes and these ligands could subsequently bind HSA. The resulting HSA-coated liposomes were as inert as conventional PEGylated liposomes in terms of macrophage recognition.

元の言語英語
ページ(範囲)2324-2331
ページ数8
ジャーナルLangmuir
34
発行部数6
DOI
出版物ステータス出版済み - 2 13 2018

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Liposomes
albumins
Serum Albumin
serums
Ligands
coatings
Coatings
ligands
macrophages
Macrophages
carboxylates
Agglomeration
membranes
Membranes

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

これを引用

Ligand-Mediated Coating of Liposomes with Human Serum Albumin. / Sato, Hikari; Nakhaei, Elnaz; Kawano, Takahito; Murata, Masaharu; Kishimura, Akihiro; Mori, Takeshi; Katayama, Yoshiki.

:: Langmuir, 巻 34, 番号 6, 13.02.2018, p. 2324-2331.

研究成果: ジャーナルへの寄稿記事

Sato, Hikari ; Nakhaei, Elnaz ; Kawano, Takahito ; Murata, Masaharu ; Kishimura, Akihiro ; Mori, Takeshi ; Katayama, Yoshiki. / Ligand-Mediated Coating of Liposomes with Human Serum Albumin. :: Langmuir. 2018 ; 巻 34, 番号 6. pp. 2324-2331.
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AU - Kishimura, Akihiro

AU - Mori, Takeshi

AU - Katayama, Yoshiki

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