Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

Shogo Haraguchi, Masaki Kamata, Takuma Tokita, Kei Ichiro Tashiro, Miku Sato, Mitsuki Nozaki, Mayumi Okamoto-Katsuyama, Isao Shimizu, Guofeng Han, Vishwajit S. Chowdhury, Xiao Feng Lei, Takuro Miyazaki, Joo Ri Kim-Kaneyama, Tomoya Nakamachi, Kouhei Matsuda, Hirokazu Ohtaki, Toshinobu Tokumoto, Tetsuya Tachibana, Akira Miyazaki, Kazuyoshi Tsutsui

研究成果: ジャーナルへの寄稿記事

抄録

The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death. Taken together, pineal ALLO mediated the effect of light on early cerebellar development in chicks

元の言語英語
ジャーナルeLife
8
出版物ステータス出版済み - 9 2019

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Pregnanolone
Brain
Purkinje Cells
Light
Cell death
Pituitary Adenylate Cyclase-Activating Polypeptide
Cell Death
Genes
Hormones
Injections

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Haraguchi, S., Kamata, M., Tokita, T., Tashiro, K. I., Sato, M., Nozaki, M., ... Tsutsui, K. (2019). Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms. eLife, 8.

Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms. / Haraguchi, Shogo; Kamata, Masaki; Tokita, Takuma; Tashiro, Kei Ichiro; Sato, Miku; Nozaki, Mitsuki; Okamoto-Katsuyama, Mayumi; Shimizu, Isao; Han, Guofeng; Chowdhury, Vishwajit S.; Lei, Xiao Feng; Miyazaki, Takuro; Kim-Kaneyama, Joo Ri; Nakamachi, Tomoya; Matsuda, Kouhei; Ohtaki, Hirokazu; Tokumoto, Toshinobu; Tachibana, Tetsuya; Miyazaki, Akira; Tsutsui, Kazuyoshi.

:: eLife, 巻 8, 09.2019.

研究成果: ジャーナルへの寄稿記事

Haraguchi, S, Kamata, M, Tokita, T, Tashiro, KI, Sato, M, Nozaki, M, Okamoto-Katsuyama, M, Shimizu, I, Han, G, Chowdhury, VS, Lei, XF, Miyazaki, T, Kim-Kaneyama, JR, Nakamachi, T, Matsuda, K, Ohtaki, H, Tokumoto, T, Tachibana, T, Miyazaki, A & Tsutsui, K 2019, 'Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms', eLife, 巻. 8.
Haraguchi S, Kamata M, Tokita T, Tashiro KI, Sato M, Nozaki M その他. Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms. eLife. 2019 9;8.
Haraguchi, Shogo ; Kamata, Masaki ; Tokita, Takuma ; Tashiro, Kei Ichiro ; Sato, Miku ; Nozaki, Mitsuki ; Okamoto-Katsuyama, Mayumi ; Shimizu, Isao ; Han, Guofeng ; Chowdhury, Vishwajit S. ; Lei, Xiao Feng ; Miyazaki, Takuro ; Kim-Kaneyama, Joo Ri ; Nakamachi, Tomoya ; Matsuda, Kouhei ; Ohtaki, Hirokazu ; Tokumoto, Toshinobu ; Tachibana, Tetsuya ; Miyazaki, Akira ; Tsutsui, Kazuyoshi. / Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms. :: eLife. 2019 ; 巻 8.
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abstract = "The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death. Taken together, pineal ALLO mediated the effect of light on early cerebellar development in chicks",
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AU - Haraguchi, Shogo

AU - Kamata, Masaki

AU - Tokita, Takuma

AU - Tashiro, Kei Ichiro

AU - Sato, Miku

AU - Nozaki, Mitsuki

AU - Okamoto-Katsuyama, Mayumi

AU - Shimizu, Isao

AU - Han, Guofeng

AU - Chowdhury, Vishwajit S.

AU - Lei, Xiao Feng

AU - Miyazaki, Takuro

AU - Kim-Kaneyama, Joo Ri

AU - Nakamachi, Tomoya

AU - Matsuda, Kouhei

AU - Ohtaki, Hirokazu

AU - Tokumoto, Toshinobu

AU - Tachibana, Tetsuya

AU - Miyazaki, Akira

AU - Tsutsui, Kazuyoshi

PY - 2019/9

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