Light chain deposition disease in an older adult patient successfully treated with long-term administration of bortezomib, melphalan and prednisone

Hiroto Hiyamuta, Shunsuke Yamada, Yuta Matsukuma, Akihiro Tsuchimoto, Toshiaki Nakano, Masatomo Taniguchi, Kosuke Masutani, Goichi Yoshimoto, Tsuyoshi Muta, Koichi Akashi, Takanari Kitazono, Kazuhiko Tsuruya

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

A 70-year-old woman was admitted to our hospital because of fatigue and renal dysfunction and was diagnosed with light chain deposition disease (LCDD) with multiple organ involvement (kidney, thyroid gland, heart and eyes). After chemotherapy with bortezomib, cyclophosphamide and dexamethasone, hepatobiliary enzyme levels increased abruptly. A liver biopsy showed light chain deposition in Disse spaces. After two years of treatment with bortezomib, melphalan and prednisone (VMP) administered at shorter intervals relative to regular cycles, the patient showed a hematological and organ response. This case indicates that a relatively low dose intensity VMP regimen is preferable for elderly patients with LCDD with multiple organ involvement.

元の言語英語
ページ(範囲)1319-1325
ページ数7
ジャーナルInternal Medicine
55
発行部数10
DOI
出版物ステータス出版済み - 1 1 2016

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Melphalan
Prednisone
Light
Kidney
Cyclophosphamide
Dexamethasone
Fatigue
Thyroid Gland
Biopsy
Drug Therapy
Liver
Enzymes
Bortezomib
Therapeutics

All Science Journal Classification (ASJC) codes

  • Internal Medicine

これを引用

Light chain deposition disease in an older adult patient successfully treated with long-term administration of bortezomib, melphalan and prednisone. / Hiyamuta, Hiroto; Yamada, Shunsuke; Matsukuma, Yuta; Tsuchimoto, Akihiro; Nakano, Toshiaki; Taniguchi, Masatomo; Masutani, Kosuke; Yoshimoto, Goichi; Muta, Tsuyoshi; Akashi, Koichi; Kitazono, Takanari; Tsuruya, Kazuhiko.

:: Internal Medicine, 巻 55, 番号 10, 01.01.2016, p. 1319-1325.

研究成果: ジャーナルへの寄稿記事

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AU - Hiyamuta, Hiroto

AU - Yamada, Shunsuke

AU - Matsukuma, Yuta

AU - Tsuchimoto, Akihiro

AU - Nakano, Toshiaki

AU - Taniguchi, Masatomo

AU - Masutani, Kosuke

AU - Yoshimoto, Goichi

AU - Muta, Tsuyoshi

AU - Akashi, Koichi

AU - Kitazono, Takanari

AU - Tsuruya, Kazuhiko

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