Lipid signaling in chemotherapy-induced peripheral neuropathy

Shota Yamamoto, Nobuaki Egashira

研究成果: ジャーナルへの寄稿総説査読

抄録

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating adverse effects observed in patients with cancer treated with neurotoxic anticancer drugs. However, there are few options for the prevention and treatment of CIPN. Lipids play essential roles in the body, as structural membrane components, energy sources, signaling molecules, and body surface barriers. Recent improvements in analytical tools and methods relevant to endogenous lipids have enabled investigation of the diverse nature of lipids in normal physiology and pathology, including their roles in acting as activators of ion channels and endogenous ligands of G protein-coupled receptors and how they affect membrane protein conformation. In this report, we summarize the crucial roles of lipid signaling in CIPN pathology.

本文言語英語
ページ(範囲)1-6
ページ数6
ジャーナルCurrent Opinion in Toxicology
28
DOI
出版ステータス出版済み - 12月 2021

!!!All Science Journal Classification (ASJC) codes

  • 毒物学

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