Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most debilitating adverse effects observed in patients with cancer treated with neurotoxic anticancer drugs. However, there are few options for the prevention and treatment of CIPN. Lipids play essential roles in the body, as structural membrane components, energy sources, signaling molecules, and body surface barriers. Recent improvements in analytical tools and methods relevant to endogenous lipids have enabled investigation of the diverse nature of lipids in normal physiology and pathology, including their roles in acting as activators of ion channels and endogenous ligands of G protein-coupled receptors and how they affect membrane protein conformation. In this report, we summarize the crucial roles of lipid signaling in CIPN pathology.
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