Lipoprotein profiling methodology based on determination of apolipoprotein concentration

Hiroaki Takeda, Yoshihiro Izumi, Atsumi Tomita, Tomonari Koike, Masashi Shiomi, Eiichiro Fukusaki, Fumio Matsuda, Takeshi Bamba

研究成果: Contribution to journalArticle査読

抄録

Aim: Abnormal lipid metabolism results in the alteration of lipid compositions in lipoproteins; therefore an accurate and quantitative analytical approach is required for the detailed structural characterization of lipoproteins. However, the specific lipid composition of each lipoprotein particle is poorly understood. Materials & methods: Lipid composition of very-low-density lipoprotein and low-density lipoprotein particles derived from myocardial infarction-prone rabbits was determined by normalization of lipidomics data using apoB-100 levels. Results: The ratio of lipid levels between very-low-density lipoprotein and low-density lipoprotein particles was different according to not only lipid classes, but also phosphatidylethanolamine subclasses by applying our developed methodology to myocardial infarction-prone rabbits. Conclusion: Our novel analytical approach represents to be a potentially useful tool to obtain particle-specific lipid components of lipoproteins.

本文言語英語
ページ(範囲)9-19
ページ数11
ジャーナルBioanalysis
9
1
DOI
出版ステータス出版済み - 1 2017

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 薬理学、毒性学および薬学(全般)
  • 臨床生化学
  • 医療検査技術

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