Liposteroid against refractory pulmonary haemorrhage in idiopathic pulmonary haemosiderosis

Shouichi Ohga, Akihiko Nomura, Naohiro Suga, Shunji Hikino, Ryutaro Kira, Akinobu Matsuzaki, Kohji Ueda, K. Masuda

研究成果: Contribution to journalArticle査読

15 被引用数 (Scopus)


We describe two Japanese children with idiopathic pulmonary haemosiderosis (IPH), whose refractory haemorrhages were treated with an intravenous lipid emulsion containing dexamethasone (liposteroid). A 22-month-old boy and a 14-month-old girl have been observed with similar symptoms; periodic bouts of anaemia, reticulocytosis, diffuse infiltrates on chest X-ray and the finding of siderophages in sputum or gastric lavage fluid. The MRI of the lung was useful for the diagnosis. Methylprednisolone pulse therapy was successful in treating acute massive bleeding. Subsequent oral prednisolone could not prevent chronic recurrent haemorrhages. However, the intermittent administration of liposteroid (0.05 mg/kg/dose IV) led to a cessation of bleeding; the haemoglobin concentration rose to normal levels. This observation emphasizes the usefulness of liposteroid in the management of refractory IPH.

ジャーナルEuropean Journal of Pediatrics
出版ステータス出版済み - 9 1994

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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