Liquid-phase immunoassay utilizing binding reactions between magnetic markers and targets in the presence of a magnetic field

Keiji Enpuku, Yuta Ueoka, Tatsuto Sakakibara, Masakazu Ura, Takashi Yoshida, Takako Mizoguchi, Akihiko Kandori

研究成果: ジャーナルへの寄稿学術誌査読

17 被引用数 (Scopus)

抄録

We developed a new and improved method for the liquid-phase detection of biological targets using magnetic markers. Unlike conventional studies, we performed a binding reaction between markers and targets in the presence of a magnetic field. This field acts to prevent the Brownian rotation of markers during the reaction. In this case, markers are bound to the targets with their magnetic moments (m's) aligned, which is in contrast to the conventional case where m's are randomly oriented after the reaction. As a result, we could obtain much larger signals from the bound markers without increasing the blank signal from the free markers.

本文言語英語
論文番号97001
ジャーナルApplied Physics Express
7
9
DOI
出版ステータス出版済み - 9月 1 2014

!!!All Science Journal Classification (ASJC) codes

  • 工学(全般)
  • 物理学および天文学(全般)

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