Liver cell-specific peptides derived from the preS1 domain of human hepatitis B virus

Jeong Hun Kang, Riki Toita, Daisuke Asai, Tetsuji Yamaoka, Masaharu Murata

    研究成果: ジャーナルへの寄稿学術誌査読

    2 被引用数 (Scopus)

    抄録

    The envelope of human hepatitis B virus (HBV) consists of the large (L), middle (M), and small (S) surface proteins. The preS1 domain at the N terminus of the L-protein is essential for recognizing a target cell and for viral infectivity. In the present study, peptides derived from the preS1 domain (amino acid residues 2-19) were synthesized, and their binding affinities for human hepatocellular carcinoma (HCC) cells were determined. Non-myristoylated peptides showed much lower affinity for HepG2 cells than myristoylated peptides. Although all peptides showed significantly higher affinities for two human HCC cell lines (HepG2 and HuH-7) compared with other cell lines (HeLa, B16, NMuLi, and NIH 3T3), a modified peptide exhibited the highest affinity for HCC cell lines. These results suggest that the modified peptide can target liver cells.

    本文言語英語
    ページ(範囲)20-23
    ページ数4
    ジャーナルJournal of Virological Methods
    201
    DOI
    出版ステータス出版済み - 6月 1 2014

    !!!All Science Journal Classification (ASJC) codes

    • ウイルス学

    フィンガープリント

    「Liver cell-specific peptides derived from the preS1 domain of human hepatitis B virus」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル