TY - JOUR
T1 - Liver cell-targeted delivery of therapeutic molecules
AU - Kang, Jeong Hun
AU - Toita, Riki
AU - Murata, Masaharu
N1 - Publisher Copyright:
© 2014 Informa Healthcare USA, Inc.
PY - 2016/1/2
Y1 - 2016/1/2
N2 - The liver is the largest internal organ in mammals and is involved in metabolism, detoxification, synthesis of proteins and lipids, secretion of cytokines and growth factors and immune/inflammatory responses. Hepatitis, alcoholic or non-alcoholic liver disease, hepatocellular carcinoma, hepatic veno-occlusive disease, and liver fibrosis and cirrhosis are the most common liver diseases. Safe and efficient delivery of therapeutic molecules (drugs, genes or proteins) into the liver is very important to increase the clinical efficacy of these molecules and to reduce their side effects in other organs. Several liver cell-targeted delivery systems have been developed and tested in vivo or ex vivo/in vitro. In this review, we discuss the literature concerning liver cell-targeted delivery systems, with a particular emphasis on the results of in vivo studies.
AB - The liver is the largest internal organ in mammals and is involved in metabolism, detoxification, synthesis of proteins and lipids, secretion of cytokines and growth factors and immune/inflammatory responses. Hepatitis, alcoholic or non-alcoholic liver disease, hepatocellular carcinoma, hepatic veno-occlusive disease, and liver fibrosis and cirrhosis are the most common liver diseases. Safe and efficient delivery of therapeutic molecules (drugs, genes or proteins) into the liver is very important to increase the clinical efficacy of these molecules and to reduce their side effects in other organs. Several liver cell-targeted delivery systems have been developed and tested in vivo or ex vivo/in vitro. In this review, we discuss the literature concerning liver cell-targeted delivery systems, with a particular emphasis on the results of in vivo studies.
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U2 - 10.3109/07388551.2014.930017
DO - 10.3109/07388551.2014.930017
M3 - Review article
C2 - 25025274
AN - SCOPUS:84949315979
VL - 36
SP - 132
EP - 143
JO - Critical Reviews in Biotechnology
JF - Critical Reviews in Biotechnology
SN - 0738-8551
IS - 1
ER -