Liver cell-targeted delivery of therapeutic molecules

Jeong Hun Kang, Riki Toita, Masaharu Murata

    研究成果: Contribution to journalReview article査読

    29 被引用数 (Scopus)

    抄録

    The liver is the largest internal organ in mammals and is involved in metabolism, detoxification, synthesis of proteins and lipids, secretion of cytokines and growth factors and immune/inflammatory responses. Hepatitis, alcoholic or non-alcoholic liver disease, hepatocellular carcinoma, hepatic veno-occlusive disease, and liver fibrosis and cirrhosis are the most common liver diseases. Safe and efficient delivery of therapeutic molecules (drugs, genes or proteins) into the liver is very important to increase the clinical efficacy of these molecules and to reduce their side effects in other organs. Several liver cell-targeted delivery systems have been developed and tested in vivo or ex vivo/in vitro. In this review, we discuss the literature concerning liver cell-targeted delivery systems, with a particular emphasis on the results of in vivo studies.

    本文言語英語
    ページ(範囲)132-143
    ページ数12
    ジャーナルCritical Reviews in Biotechnology
    36
    1
    DOI
    出版ステータス出版済み - 1 2 2016

    All Science Journal Classification (ASJC) codes

    • バイオテクノロジー
    • 応用微生物学とバイオテクノロジー

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