Liver retransplantation for primary nonfunction: Analysis of a 20-year single-center experience

Tadahiro Uemura, Henry B. Randall, Edmund Q. Sanchez, Toru Ikegami, Gomathy Narasimhan, Greg J. McKenna, Srinath Chinnakotla, Marlon F. Levy, Robert M. Goldstein, Goran B. Klintmalm

研究成果: ジャーナルへの寄稿記事

82 引用 (Scopus)

抄録

Initial graft function following liver transplantation is a major determinant of postoperative survival and morbidity. Primary graft nonfunction (PNF) is uncommon; however, it is one of the most serious and life-threatening conditions in the immediate postoperative period. The risk factors associated with PNF and short-term outcome have been previously reported, but there are no reports of long-term follow-up after retransplant for PNF. At our institution, 52 liver transplants had PNF (2.22%) among 2,341 orthotopic liver transplants in 2,130 patients from 1984 to 2003. PNF occurred more often in the retransplant setting. Female donors, donor age, donor days in the intensive care unit, cold ischemia time, and operating room time were significant factors for PNF. Patient as well as graft survival of retransplant for PNF was not different compared to retransplant for other causes. However, PNF for a second or third transplant did not demonstrate long-term survival, and hospital mortality was 57%. In conclusion, retransplant for PNF in the initial transplant can achieve relatively good long-term survival; however, if another transplant is needed in the setting of a second PNF, the third retransplant should probably not be done due to poor expected outcome.

元の言語英語
ページ(範囲)227-233
ページ数7
ジャーナルLiver Transplantation
13
発行部数2
DOI
出版物ステータス出版済み - 2 1 2007
外部発表Yes

Fingerprint

Transplants
Liver
Tissue Donors
Survival
Cold Ischemia
Graft Survival
Operating Rooms
Hospital Mortality
Postoperative Period
Liver Transplantation
Intensive Care Units
Morbidity

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

これを引用

Uemura, T., Randall, H. B., Sanchez, E. Q., Ikegami, T., Narasimhan, G., McKenna, G. J., ... Klintmalm, G. B. (2007). Liver retransplantation for primary nonfunction: Analysis of a 20-year single-center experience. Liver Transplantation, 13(2), 227-233. https://doi.org/10.1002/lt.20992

Liver retransplantation for primary nonfunction : Analysis of a 20-year single-center experience. / Uemura, Tadahiro; Randall, Henry B.; Sanchez, Edmund Q.; Ikegami, Toru; Narasimhan, Gomathy; McKenna, Greg J.; Chinnakotla, Srinath; Levy, Marlon F.; Goldstein, Robert M.; Klintmalm, Goran B.

:: Liver Transplantation, 巻 13, 番号 2, 01.02.2007, p. 227-233.

研究成果: ジャーナルへの寄稿記事

Uemura, T, Randall, HB, Sanchez, EQ, Ikegami, T, Narasimhan, G, McKenna, GJ, Chinnakotla, S, Levy, MF, Goldstein, RM & Klintmalm, GB 2007, 'Liver retransplantation for primary nonfunction: Analysis of a 20-year single-center experience', Liver Transplantation, 巻. 13, 番号 2, pp. 227-233. https://doi.org/10.1002/lt.20992
Uemura, Tadahiro ; Randall, Henry B. ; Sanchez, Edmund Q. ; Ikegami, Toru ; Narasimhan, Gomathy ; McKenna, Greg J. ; Chinnakotla, Srinath ; Levy, Marlon F. ; Goldstein, Robert M. ; Klintmalm, Goran B. / Liver retransplantation for primary nonfunction : Analysis of a 20-year single-center experience. :: Liver Transplantation. 2007 ; 巻 13, 番号 2. pp. 227-233.
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