Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the human hair follicle

Chikage Mitoma, Futoshi Kohda, Yukihiro Mizote, Akira Miake, Ayako Ijichi, Saho Kawahara, Miki Kohno, Hiroko Sonoyama, Yasutaka Mitamura, Yumiko Kaku, Hiroko Inoue, Yoshiko Sasaki, Fumitaka Ohno, Noriko Okabe, Nobutoshi Take, Mika Mizote, Akiko Masuda, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

The hair follicle is a highly differentiated structure. In this study, we examined immunohistological localization of S100A2, S100A4, S100A6, S100A7, and S100P using specific monoclonal antibodies. S100A2 was strongly expressed in the entire outer-root sheath (ORS), but more weakly in cuticle and medulla in the bulb. S100A6, S100A7, and S100P were expressed in the innermost cells of ORS. The cuticular area was weakly positive for S100A2, S100A6, S100A7, and S100P. S100A4 was expressed in dendritic Langerhans cells and melanocytes. Sebaceous cells were variably immunopositive for S100A2, S100A6, and S100A7. A subset of dermal papilla cells expressed S100A4 and S100A6. None of the antibodies labeled the inner-root sheath. The distinct spatiostructural distributions of the S100 family proteins suggest that each protein is differentially involved in the physiological function of normal hair follicles.

元の言語英語
ページ(範囲)148-156
ページ数9
ジャーナルFukuoka igaku zasshi = Hukuoka acta medica
105
発行部数7
出版物ステータス出版済み - 7 1 2014

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Hair Follicle
Langerhans Cells
S100 Proteins
Melanocytes
Dendritic Cells
Monoclonal Antibodies
Skin
Antibodies
Proteins

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Mitoma, C., Kohda, F., Mizote, Y., Miake, A., Ijichi, A., Kawahara, S., ... Furue, M. (2014). Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the human hair follicle. Fukuoka igaku zasshi = Hukuoka acta medica, 105(7), 148-156.

Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the human hair follicle. / Mitoma, Chikage; Kohda, Futoshi; Mizote, Yukihiro; Miake, Akira; Ijichi, Ayako; Kawahara, Saho; Kohno, Miki; Sonoyama, Hiroko; Mitamura, Yasutaka; Kaku, Yumiko; Inoue, Hiroko; Sasaki, Yoshiko; Ohno, Fumitaka; Okabe, Noriko; Take, Nobutoshi; Mizote, Mika; Masuda, Akiko; Furue, Masutaka.

:: Fukuoka igaku zasshi = Hukuoka acta medica, 巻 105, 番号 7, 01.07.2014, p. 148-156.

研究成果: ジャーナルへの寄稿記事

Mitoma, C, Kohda, F, Mizote, Y, Miake, A, Ijichi, A, Kawahara, S, Kohno, M, Sonoyama, H, Mitamura, Y, Kaku, Y, Inoue, H, Sasaki, Y, Ohno, F, Okabe, N, Take, N, Mizote, M, Masuda, A & Furue, M 2014, 'Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the human hair follicle', Fukuoka igaku zasshi = Hukuoka acta medica, 巻. 105, 番号 7, pp. 148-156.
Mitoma C, Kohda F, Mizote Y, Miake A, Ijichi A, Kawahara S その他. Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the human hair follicle. Fukuoka igaku zasshi = Hukuoka acta medica. 2014 7 1;105(7):148-156.
Mitoma, Chikage ; Kohda, Futoshi ; Mizote, Yukihiro ; Miake, Akira ; Ijichi, Ayako ; Kawahara, Saho ; Kohno, Miki ; Sonoyama, Hiroko ; Mitamura, Yasutaka ; Kaku, Yumiko ; Inoue, Hiroko ; Sasaki, Yoshiko ; Ohno, Fumitaka ; Okabe, Noriko ; Take, Nobutoshi ; Mizote, Mika ; Masuda, Akiko ; Furue, Masutaka. / Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the human hair follicle. :: Fukuoka igaku zasshi = Hukuoka acta medica. 2014 ; 巻 105, 番号 7. pp. 148-156.
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abstract = "The hair follicle is a highly differentiated structure. In this study, we examined immunohistological localization of S100A2, S100A4, S100A6, S100A7, and S100P using specific monoclonal antibodies. S100A2 was strongly expressed in the entire outer-root sheath (ORS), but more weakly in cuticle and medulla in the bulb. S100A6, S100A7, and S100P were expressed in the innermost cells of ORS. The cuticular area was weakly positive for S100A2, S100A6, S100A7, and S100P. S100A4 was expressed in dendritic Langerhans cells and melanocytes. Sebaceous cells were variably immunopositive for S100A2, S100A6, and S100A7. A subset of dermal papilla cells expressed S100A4 and S100A6. None of the antibodies labeled the inner-root sheath. The distinct spatiostructural distributions of the S100 family proteins suggest that each protein is differentially involved in the physiological function of normal hair follicles.",
author = "Chikage Mitoma and Futoshi Kohda and Yukihiro Mizote and Akira Miake and Ayako Ijichi and Saho Kawahara and Miki Kohno and Hiroko Sonoyama and Yasutaka Mitamura and Yumiko Kaku and Hiroko Inoue and Yoshiko Sasaki and Fumitaka Ohno and Noriko Okabe and Nobutoshi Take and Mika Mizote and Akiko Masuda and Masutaka Furue",
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T1 - Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the human hair follicle

AU - Mitoma, Chikage

AU - Kohda, Futoshi

AU - Mizote, Yukihiro

AU - Miake, Akira

AU - Ijichi, Ayako

AU - Kawahara, Saho

AU - Kohno, Miki

AU - Sonoyama, Hiroko

AU - Mitamura, Yasutaka

AU - Kaku, Yumiko

AU - Inoue, Hiroko

AU - Sasaki, Yoshiko

AU - Ohno, Fumitaka

AU - Okabe, Noriko

AU - Take, Nobutoshi

AU - Mizote, Mika

AU - Masuda, Akiko

AU - Furue, Masutaka

PY - 2014/7/1

Y1 - 2014/7/1

N2 - The hair follicle is a highly differentiated structure. In this study, we examined immunohistological localization of S100A2, S100A4, S100A6, S100A7, and S100P using specific monoclonal antibodies. S100A2 was strongly expressed in the entire outer-root sheath (ORS), but more weakly in cuticle and medulla in the bulb. S100A6, S100A7, and S100P were expressed in the innermost cells of ORS. The cuticular area was weakly positive for S100A2, S100A6, S100A7, and S100P. S100A4 was expressed in dendritic Langerhans cells and melanocytes. Sebaceous cells were variably immunopositive for S100A2, S100A6, and S100A7. A subset of dermal papilla cells expressed S100A4 and S100A6. None of the antibodies labeled the inner-root sheath. The distinct spatiostructural distributions of the S100 family proteins suggest that each protein is differentially involved in the physiological function of normal hair follicles.

AB - The hair follicle is a highly differentiated structure. In this study, we examined immunohistological localization of S100A2, S100A4, S100A6, S100A7, and S100P using specific monoclonal antibodies. S100A2 was strongly expressed in the entire outer-root sheath (ORS), but more weakly in cuticle and medulla in the bulb. S100A6, S100A7, and S100P were expressed in the innermost cells of ORS. The cuticular area was weakly positive for S100A2, S100A6, S100A7, and S100P. S100A4 was expressed in dendritic Langerhans cells and melanocytes. Sebaceous cells were variably immunopositive for S100A2, S100A6, and S100A7. A subset of dermal papilla cells expressed S100A4 and S100A6. None of the antibodies labeled the inner-root sheath. The distinct spatiostructural distributions of the S100 family proteins suggest that each protein is differentially involved in the physiological function of normal hair follicles.

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