Logical design of oral glucose ingestion pattern minimizing blood glucose in humans

Masashi Fujii, Yohei Murakami, Yasuaki Karasawa, Yohei Sumitomo, Suguru Fujita, Masanori Koyama, Shinsuke Uda, Hiroyuki Kubota, Hiroshi Inoue, Katsumi Konishi, Shigeyuki Oba, Shin Ishii, Shinya Kuroda

研究成果: Contribution to journalArticle

抄録

Excessive increase in blood glucose level after eating increases the risk of macroangiopathy, and a method for not increasing the postprandial blood glucose level is desired. However, a logical design method of the dietary ingestion pattern controlling the postprandial blood glucose level has not yet been established. We constructed a mathematical model of blood glucose control by oral glucose ingestion in three healthy human subjects, and predicted that intermittent ingestion 30 min apart was the optimal glucose ingestion patterns that minimized the peak value of blood glucose level. We confirmed with subjects that this intermittent pattern consistently decreased the peak value of blood glucose level. We also predicted insulin minimization pattern, and found that the intermittent ingestion 30 min apart was optimal, which is similar to that of glucose minimization pattern. Taken together, these results suggest that the glucose minimization is achieved by suppressing the peak value of insulin concentration, rather than by enhancing insulin concentration. This approach could be applied to design optimal dietary ingestion patterns.

本文言語英語
論文番号31
ジャーナルnpj Systems Biology and Applications
5
1
DOI
出版ステータス出版済み - 12 1 2019

All Science Journal Classification (ASJC) codes

  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Drug Discovery
  • Computer Science Applications
  • Applied Mathematics

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