Long-day suppressed expression of type 2 deiodinase gene in the mediobasal hypothalamus of the Saanen goat, a short-day breeder: Implication for seasonal window of thyroid hormone action on reproductive neuroendocrine axis

Shinobu Yasuo, Nobuhiro Nakao, Satoshi Ohkura, Masayuki Iigo, Satoko Hagiwara, Akemitsu Goto, Hiroshi Ando, Takashi Yamamura, Miwa Watanabe, Tsuyoshi Watanabe, Sen Ichi Oda, Kei Ichiro Maeda, Gerald A. Lincoln, Hiroaki Okamura, Shizufumi Ebihara, Takashi Yoshimura

研究成果: ジャーナルへの寄稿学術誌査読

82 被引用数 (Scopus)

抄録

In most animals that live in temperate regions, reproduction is under photoperiodic control. In long-day breeders such as Japanese quail and Djungarian hamsters, type 2 deiodinase (Dio2) plays an important role in the mediobasal hypothalamus, catalyzing the conversion of prohormone T4 to bioactive T3 to regulate the photoperiodic response of the gonads. However, the molecular basis for seasonal reproduction in shortday breeders remains unclear. Because thyroid hormones are also known to be involved in short-day breeders, we examined the effect of an artificial long-day stimulus on Dio2 expression in the male Saanen goat (Capra hircus), a short-day breeder. Dio2 expression was observed in the caudal continuation of the arcuate nucleus, known as the target site for both melatonin and T4 action. In addition, expression of Dio2 and T3 content in the mediobasal hypothalamus was suppressed by artificial long-day conditions, which is the opposite of the results of long-day breeders. Thyroid hormone action on the development of neuroendocrine anestrus is known to be limited to a specific seasonal window. This long-day suppression of Dio2 may provide a mechanism that accounts for the lack of responsiveness to thyroxine during the mid to late anestrus.

本文言語英語
ページ(範囲)432-440
ページ数9
ジャーナルEndocrinology
147
1
DOI
出版ステータス出版済み - 1月 2006
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 内分泌学

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