Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain

Toshihide Kuroki, Takashi Matsumoto, Makoto Hirano, Hiroshi Kagoshima, Hiroshi Yao, Hideyuki Uchimura, Kaoru Nakamura, Tatsuo Nakahara

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

抄録

The effect of systemically administrated cholecystokinin analog, caerulein, on monoaminergic neurons was examined in discrete regions of rat brain. A single injection of caerulein (400 μg/kg, i.p.) significantly elevated 5-hydroxyindoleacetic acid (5HIAA) levels in the prefrontal cortex lateral field, nucleus accumbens, tuberculum olfactorium and striatum after 2 hours, together with a significant increase in striatal serotonin (5HT). Moreover, the time-course study showed that the caerulein-induced increase in both 5HIAA and 5HT levels lasted even for 24 hours, and their levels tended to recover to the control values gradually. This time-dependent change was not found in the other monoamines and their metabolites. These results suggest a long-lasting action of caerulein on 5HT neurons in specific regions of rat brain.

元の言語英語
ページ(範囲)169-176
ページ数8
ジャーナルNeuropeptides
9
発行部数2
DOI
出版物ステータス出版済み - 1 1 1987

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Ceruletide
Hydroxyindoleacetic Acid
Brain
Neurons
Corpus Striatum
Cholecystokinin
Nucleus Accumbens
Prefrontal Cortex
Serotonin
Injections

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

これを引用

Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain. / Kuroki, Toshihide; Matsumoto, Takashi; Hirano, Makoto; Kagoshima, Hiroshi; Yao, Hiroshi; Uchimura, Hideyuki; Nakamura, Kaoru; Nakahara, Tatsuo.

:: Neuropeptides, 巻 9, 番号 2, 01.01.1987, p. 169-176.

研究成果: ジャーナルへの寄稿記事

Kuroki, T, Matsumoto, T, Hirano, M, Kagoshima, H, Yao, H, Uchimura, H, Nakamura, K & Nakahara, T 1987, 'Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain', Neuropeptides, 巻. 9, 番号 2, pp. 169-176. https://doi.org/10.1016/0143-4179(87)90055-2
Kuroki, Toshihide ; Matsumoto, Takashi ; Hirano, Makoto ; Kagoshima, Hiroshi ; Yao, Hiroshi ; Uchimura, Hideyuki ; Nakamura, Kaoru ; Nakahara, Tatsuo. / Long-lasting effect of systemically administrated caerulein on monoaminergic neuronal pathways in rat brain. :: Neuropeptides. 1987 ; 巻 9, 番号 2. pp. 169-176.
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