Long-term dietary supplementation with the green tea cultivar Sunrouge prevents age-related cognitive decline in the senescence-accelerated mouse Prone8

Masafumi Wasai, Haruna Nonaka, Motoki Murata, Ryo Kitamura, Yuka Sato, Hirofumi Tachibana

研究成果: ジャーナルへの寄稿記事

抄録

A majority of the potential health benefits of green tea, including the potential to prevent cognitive decline, have been attributed to epigallocatechin gallate (EGCG). Sunrouge is a green tea cultivar that contains EGCG and several other bioactive components such as quercetin, myricetin, cyanidin and delphinidin. We compared the effects of Sunrouge and Yabukita, the most popular Japanese green tea cultivar, on cognitive function in the senescence-accelerated mouse Prone8. These mice were fed an experimental diet containing Sunrouge extract (SRE) or Yabukita extract (YBE). SRE feeding significantly prevented cognitive decline, whereas YBE feeding had little effect. Moreover, SRE feeding prevented elevation of the amyloid-β42 level while improving the gene expression of neprilysin and decreasing beta-site APP-cleaving enzyme 1 in the brain. These preventive effects of SRE against cognitive decline were attributed to the characteristic composition of Sunrouge and strongly suggest that consumption of this cultivar could protect against age-related cognitive decline.

元の言語英語
ページ(範囲)339-347
ページ数9
ジャーナルBioscience, Biotechnology and Biochemistry
83
発行部数2
DOI
出版物ステータス出版済み - 1 1 2019

Fingerprint

Tea
Dietary Supplements
delphinidin
Neprilysin
Quercetin
Nutrition
Amyloid
Gene expression
Brain
Insurance Benefits
Health
Cognition
Enzymes
Diet
Chemical analysis
Gene Expression
Cognitive Dysfunction
epigallocatechin gallate

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

これを引用

Long-term dietary supplementation with the green tea cultivar Sunrouge prevents age-related cognitive decline in the senescence-accelerated mouse Prone8. / Wasai, Masafumi; Nonaka, Haruna; Murata, Motoki; Kitamura, Ryo; Sato, Yuka; Tachibana, Hirofumi.

:: Bioscience, Biotechnology and Biochemistry, 巻 83, 番号 2, 01.01.2019, p. 339-347.

研究成果: ジャーナルへの寄稿記事

@article{06000af7dfc9421087b4992e27e83610,
title = "Long-term dietary supplementation with the green tea cultivar Sunrouge prevents age-related cognitive decline in the senescence-accelerated mouse Prone8",
abstract = "A majority of the potential health benefits of green tea, including the potential to prevent cognitive decline, have been attributed to epigallocatechin gallate (EGCG). Sunrouge is a green tea cultivar that contains EGCG and several other bioactive components such as quercetin, myricetin, cyanidin and delphinidin. We compared the effects of Sunrouge and Yabukita, the most popular Japanese green tea cultivar, on cognitive function in the senescence-accelerated mouse Prone8. These mice were fed an experimental diet containing Sunrouge extract (SRE) or Yabukita extract (YBE). SRE feeding significantly prevented cognitive decline, whereas YBE feeding had little effect. Moreover, SRE feeding prevented elevation of the amyloid-β42 level while improving the gene expression of neprilysin and decreasing beta-site APP-cleaving enzyme 1 in the brain. These preventive effects of SRE against cognitive decline were attributed to the characteristic composition of Sunrouge and strongly suggest that consumption of this cultivar could protect against age-related cognitive decline.",
author = "Masafumi Wasai and Haruna Nonaka and Motoki Murata and Ryo Kitamura and Yuka Sato and Hirofumi Tachibana",
year = "2019",
month = "1",
day = "1",
doi = "10.1080/09168451.2018.1530093",
language = "English",
volume = "83",
pages = "339--347",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "2",

}

TY - JOUR

T1 - Long-term dietary supplementation with the green tea cultivar Sunrouge prevents age-related cognitive decline in the senescence-accelerated mouse Prone8

AU - Wasai, Masafumi

AU - Nonaka, Haruna

AU - Murata, Motoki

AU - Kitamura, Ryo

AU - Sato, Yuka

AU - Tachibana, Hirofumi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - A majority of the potential health benefits of green tea, including the potential to prevent cognitive decline, have been attributed to epigallocatechin gallate (EGCG). Sunrouge is a green tea cultivar that contains EGCG and several other bioactive components such as quercetin, myricetin, cyanidin and delphinidin. We compared the effects of Sunrouge and Yabukita, the most popular Japanese green tea cultivar, on cognitive function in the senescence-accelerated mouse Prone8. These mice were fed an experimental diet containing Sunrouge extract (SRE) or Yabukita extract (YBE). SRE feeding significantly prevented cognitive decline, whereas YBE feeding had little effect. Moreover, SRE feeding prevented elevation of the amyloid-β42 level while improving the gene expression of neprilysin and decreasing beta-site APP-cleaving enzyme 1 in the brain. These preventive effects of SRE against cognitive decline were attributed to the characteristic composition of Sunrouge and strongly suggest that consumption of this cultivar could protect against age-related cognitive decline.

AB - A majority of the potential health benefits of green tea, including the potential to prevent cognitive decline, have been attributed to epigallocatechin gallate (EGCG). Sunrouge is a green tea cultivar that contains EGCG and several other bioactive components such as quercetin, myricetin, cyanidin and delphinidin. We compared the effects of Sunrouge and Yabukita, the most popular Japanese green tea cultivar, on cognitive function in the senescence-accelerated mouse Prone8. These mice were fed an experimental diet containing Sunrouge extract (SRE) or Yabukita extract (YBE). SRE feeding significantly prevented cognitive decline, whereas YBE feeding had little effect. Moreover, SRE feeding prevented elevation of the amyloid-β42 level while improving the gene expression of neprilysin and decreasing beta-site APP-cleaving enzyme 1 in the brain. These preventive effects of SRE against cognitive decline were attributed to the characteristic composition of Sunrouge and strongly suggest that consumption of this cultivar could protect against age-related cognitive decline.

UR - http://www.scopus.com/inward/record.url?scp=85060369991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060369991&partnerID=8YFLogxK

U2 - 10.1080/09168451.2018.1530093

DO - 10.1080/09168451.2018.1530093

M3 - Article

C2 - 30295144

AN - SCOPUS:85060369991

VL - 83

SP - 339

EP - 347

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 2

ER -