Long-term favorable response to interferon beta-1b is linked to cytokine deviation toward the Th2 and Tc2 sides in Japanese patients with multiple sclerosis

Feng Jun Mei, Manabu Osoegawa, Hirofumi Ochi, Motozumi Minohara, Shi Nan, Hiroyuki Murai, Takaaki Ishizu, Takayuki Taniwaki, Jun ichi Kira

研究成果: ジャーナルへの寄稿学術誌査読

17 被引用数 (Scopus)

抄録

To address the immune mechanism of the long-term beneficial effects of interferon beta (IFN-β), we measured the intracellular cytokine production patterns of IFN-γ, IL-4 and IL-13 in peripheral blood CD4+ and CD8+ T cells, which previously displayed alterations during the early course of IFN-β treatment, in 15 Japanese patients after long-term IFN-β administration. The patients were treated with IFN-β-1b 8 × 106 units given subcutaneously every other day for a mean period of 34.5 ± 5.5 months (range: 26-43 months). During the follow-up period, 6 patients experienced 33 relapses, while the other 9 were relapse-free. The results revealed the following cytokine alterations: (1) type 2 cytokine, such as IL-4 and IL-13, were significantly increased in producing cell percentages in both CD4+ (p = 0.0356 and p = 0.0007, respectively) and CD8+ (p = 0.0231 and p = 0.0170, respectively) T cells while IFN-γ, a representative type 1 cytokine, was significantly decreased in the absolute producing cell numbers (p = 0.0125 in CD4+ T cells and p = 0.0022 in CD8+ T cells) even after approximately 3 years of IFN-β administration; (2) the intracellular IFN-γ / IL-4 ratio tended to decrease in both CD4+ and CD8+ T cells (p = 0.0535 and p = 0.0783, respectively), reflecting a strong downmodulation of type 1 cytokine producing cells; and importantly (3) alterations such as the decreased intracellular IFN-γ / IL-4 ratio in CD4+ T cells and increased percentage of CD8+ IL-13+ T cells compared with the pretreatment levels were only statistically significant in MS patients without relapse during IFN-β therapy (p = 0.0152 and p = 0.0078, respectively). Therefore, we consider that cytokine deviation toward the Th2 and Tc2 sides is linked to a long-term favorable response to IFN-β, while a higher intracellular IFN-γ / IL-4 ratio is associated with treatment failure.

本文言語英語
ページ(範囲)71-77
ページ数7
ジャーナルJournal of the Neurological Sciences
246
1-2
DOI
出版ステータス出版済み - 7月 15 2006

!!!All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学

フィンガープリント

「Long-term favorable response to interferon beta-1b is linked to cytokine deviation toward the Th2 and Tc2 sides in Japanese patients with multiple sclerosis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル