Long-term favorable surgical results of laparoscopic hepatic resection for hepatocellular carcinoma in patients with cirrhosis: A single-center experience over a 10-year periods

Yo Ichi Yamashita, Tetsuo Ikeda, Takeshi Kurihara, Yoshihiro Yoshida, kazuki takeishi, shinji itoh, Norifumi Harimoto, Hirofumi Kawanaka, Ken Shirabe, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿記事

39 引用 (Scopus)

抄録

Background: We first performed laparoscopic hepatic resection (Lap-Hx) for hepatocellular carcinoma (HCC) in 1994. Here we review the long-term surgical results of Lap-Hx for HCC in patients with cirrhosis over a 10-year period at a single institution. Study Design: Between January 2000 and December 2013, 99 patients with cirrhosis underwent open hepatic resection (Open-Hx) and 63 underwent Lap-Hx for primary HCC within the Milan criteria. We compared the operative outcomes and patient survival between the 2 groups. RESULTS: There were no significant differences regarding patient background characteristics or tumorrelated factors between the 2 groups. The morbidity rate of the Lap-Hx group was significantly lower than that of the Open-Hx group (26% vs 10%; p = 0.0459), and the complication rate of ascites was significantly lower (7% vs 0%; p = 0.0077). The mean duration of hospital stay of the Lap-Hx group was significantly shorter than that of the Open-Hx group (16 vs 10 days; p = 0.0008). There were no significant between-group differences regarding overall or disease-free survival. Conclusions: Laparoscopic-Hx for HCC in patients with cirrhosis is associated with less morbidity and shorter hospital stays, with no compromise in patient survival. It may be time to consider changing the standard operation for primary HCC within the Milan criteria to Lap-Hx in patients with cirrhosis.

元の言語英語
ページ(範囲)1117-1123
ページ数7
ジャーナルJournal of the American College of Surgeons
219
発行部数6
DOI
出版物ステータス出版済み - 1 1 2014

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Hepatocellular Carcinoma
Fibrosis
Liver
Length of Stay
Morbidity
Survival
Ascites
Disease-Free Survival

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Long-term favorable surgical results of laparoscopic hepatic resection for hepatocellular carcinoma in patients with cirrhosis : A single-center experience over a 10-year periods. / Yamashita, Yo Ichi; Ikeda, Tetsuo; Kurihara, Takeshi; Yoshida, Yoshihiro; takeishi, kazuki; itoh, shinji; Harimoto, Norifumi; Kawanaka, Hirofumi; Shirabe, Ken; Maehara, Yoshihiko.

:: Journal of the American College of Surgeons, 巻 219, 番号 6, 01.01.2014, p. 1117-1123.

研究成果: ジャーナルへの寄稿記事

Yamashita, Yo Ichi ; Ikeda, Tetsuo ; Kurihara, Takeshi ; Yoshida, Yoshihiro ; takeishi, kazuki ; itoh, shinji ; Harimoto, Norifumi ; Kawanaka, Hirofumi ; Shirabe, Ken ; Maehara, Yoshihiko. / Long-term favorable surgical results of laparoscopic hepatic resection for hepatocellular carcinoma in patients with cirrhosis : A single-center experience over a 10-year periods. :: Journal of the American College of Surgeons. 2014 ; 巻 219, 番号 6. pp. 1117-1123.
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abstract = "Background: We first performed laparoscopic hepatic resection (Lap-Hx) for hepatocellular carcinoma (HCC) in 1994. Here we review the long-term surgical results of Lap-Hx for HCC in patients with cirrhosis over a 10-year period at a single institution. Study Design: Between January 2000 and December 2013, 99 patients with cirrhosis underwent open hepatic resection (Open-Hx) and 63 underwent Lap-Hx for primary HCC within the Milan criteria. We compared the operative outcomes and patient survival between the 2 groups. RESULTS: There were no significant differences regarding patient background characteristics or tumorrelated factors between the 2 groups. The morbidity rate of the Lap-Hx group was significantly lower than that of the Open-Hx group (26{\%} vs 10{\%}; p = 0.0459), and the complication rate of ascites was significantly lower (7{\%} vs 0{\%}; p = 0.0077). The mean duration of hospital stay of the Lap-Hx group was significantly shorter than that of the Open-Hx group (16 vs 10 days; p = 0.0008). There were no significant between-group differences regarding overall or disease-free survival. Conclusions: Laparoscopic-Hx for HCC in patients with cirrhosis is associated with less morbidity and shorter hospital stays, with no compromise in patient survival. It may be time to consider changing the standard operation for primary HCC within the Milan criteria to Lap-Hx in patients with cirrhosis.",
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AU - Yamashita, Yo Ichi

AU - Ikeda, Tetsuo

AU - Kurihara, Takeshi

AU - Yoshida, Yoshihiro

AU - takeishi, kazuki

AU - itoh, shinji

AU - Harimoto, Norifumi

AU - Kawanaka, Hirofumi

AU - Shirabe, Ken

AU - Maehara, Yoshihiko

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AB - Background: We first performed laparoscopic hepatic resection (Lap-Hx) for hepatocellular carcinoma (HCC) in 1994. Here we review the long-term surgical results of Lap-Hx for HCC in patients with cirrhosis over a 10-year period at a single institution. Study Design: Between January 2000 and December 2013, 99 patients with cirrhosis underwent open hepatic resection (Open-Hx) and 63 underwent Lap-Hx for primary HCC within the Milan criteria. We compared the operative outcomes and patient survival between the 2 groups. RESULTS: There were no significant differences regarding patient background characteristics or tumorrelated factors between the 2 groups. The morbidity rate of the Lap-Hx group was significantly lower than that of the Open-Hx group (26% vs 10%; p = 0.0459), and the complication rate of ascites was significantly lower (7% vs 0%; p = 0.0077). The mean duration of hospital stay of the Lap-Hx group was significantly shorter than that of the Open-Hx group (16 vs 10 days; p = 0.0008). There were no significant between-group differences regarding overall or disease-free survival. Conclusions: Laparoscopic-Hx for HCC in patients with cirrhosis is associated with less morbidity and shorter hospital stays, with no compromise in patient survival. It may be time to consider changing the standard operation for primary HCC within the Milan criteria to Lap-Hx in patients with cirrhosis.

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