Long-term follow-up study of seventeen cases with Wilson's disease

K. Tanaka, Y. Itoyama, S. Tobimatsu, I. Goto, Y. Kuroiwa

研究成果: ジャーナルへの寄稿記事

抄録

We performed a follow-up study of 17 patients with Wilson's disease (6 men, 11 women) in order to evaluate the effect of penicillamine therapy. All patients have been treated with penicillamine for 1 to 17 years. The severity in the patients were evaluated by using the grading system (Grade 0 to 4) reported by Goldstein et al. Six of 17 patients showed improvement, 6 patients showed no change of severity and 4 patients died in spite of the treatment. One patient has been asymptomatic for 7 years by treatment. An improvement was observed in the group treated with penicillamine more than 600 mg/day, and also the group treated for longer than 5 years. There was no relationship between the severity before treatment and the subsequent effects of treatment. These results suggest that a dosage of penicillamine and the duration of the treatment are important factors of clinical improvement of the patients.

元の言語英語
ページ(範囲)1261-1264
ページ数4
ジャーナルClinical Neurology
25
発行部数11
出版物ステータス出版済み - 12 1 1985

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Hepatolenticular Degeneration
Penicillamine
Therapeutics

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

これを引用

Tanaka, K., Itoyama, Y., Tobimatsu, S., Goto, I., & Kuroiwa, Y. (1985). Long-term follow-up study of seventeen cases with Wilson's disease. Clinical Neurology, 25(11), 1261-1264.

Long-term follow-up study of seventeen cases with Wilson's disease. / Tanaka, K.; Itoyama, Y.; Tobimatsu, S.; Goto, I.; Kuroiwa, Y.

:: Clinical Neurology, 巻 25, 番号 11, 01.12.1985, p. 1261-1264.

研究成果: ジャーナルへの寄稿記事

Tanaka, K, Itoyama, Y, Tobimatsu, S, Goto, I & Kuroiwa, Y 1985, 'Long-term follow-up study of seventeen cases with Wilson's disease', Clinical Neurology, 巻. 25, 番号 11, pp. 1261-1264.
Tanaka K, Itoyama Y, Tobimatsu S, Goto I, Kuroiwa Y. Long-term follow-up study of seventeen cases with Wilson's disease. Clinical Neurology. 1985 12 1;25(11):1261-1264.
Tanaka, K. ; Itoyama, Y. ; Tobimatsu, S. ; Goto, I. ; Kuroiwa, Y. / Long-term follow-up study of seventeen cases with Wilson's disease. :: Clinical Neurology. 1985 ; 巻 25, 番号 11. pp. 1261-1264.
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