Long-term outcome of infants with twin-to-twin transfusion syndrome

Shunji Hikino, Shouichi Ohga, Takashi Kanda, Toshinori Nakashima, Junko Yamamoto, Hideki Nakayama, Hitoo Nakano, Toshiro Hara

研究成果: ジャーナルへの寄稿学術誌査読

11 被引用数 (Scopus)


Objective: To clarify the long-term neurodevelopmental outcome of twin-to-twin transfusion syndrome (TTTS) survivors. Methods: From January 1994 to December 2003, 33 newborns with TTTS who were derived from 18 monochorionic twin gestations were enrolled for the study. The development and growth at 3 or 6 years of age were compared between TTTS survivors and weight-matched singleton controls. Results: The mortality in TTTS (8/33: 24%) was significantly higher than that of the controls (7/80: 9%). Of all 12 TTTS patients who were diagnosed before 25 weeks and born before 28 weeks of gestation, in 10 (83%) it led to neonatal or intrauterine death. The morbidity of cerebral palsy, epilepsy, and mental retardation did not differ between TTTS and control patients. The morbidity and severity of neurological deficits at school age were similar in both groups. No growth parameters at 3 or 6 years of age differed between TTTS and controls. Conclusions: Morbidity, growth and development of TTTS survivors attained comparable levels of weight-matched controls, despite the higher neonatal mortality. These results suggest that the early management of TTTS is critical for refining the total outcome of the affected twins.

ジャーナルFetal Diagnosis and Therapy
出版ステータス出版済み - 12月 2006

!!!All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 胎生学
  • 放射線学、核医学およびイメージング
  • 産婦人科学


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