Long-term outcome of S-1 and cisplatin combination therapy in patients with advanced or recurrent gastric cancer

Yoshihisa Sakaguchi, Akira Kabashima, Keishi Okita, Yasutomo Ojima, Shinji Yamamura, Takashi Nishizaki, Hideya Tashiro, Toshimitsu Matsusaka

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

Background. Although combination therapy of S-1 and cisplatin (CDDP) has excellent efficacy against gastric cancer, the effect of the treatment on survival has been unclear. The aim of this study was to evaluate the long-term outcome of this combination therapy. Methods. Sixty-three patients with advanced or recurrent gastric cancer were treated with S-1, with or without CDDP, as first-line chemotherapy, and the clinical results were compared retrospectively. S-1 was administered orally at a standard dose of 80mg/m2. In the treatment of the S-1 group, S-1 was given for 28 consecutive days, followed by a 14-day rest. In the treatment of the S-1/CDDP group, S-1 was given for 21 consecutive days, followed by a 14-day rest, and CDDP, at 60mg/m2, was infused on day 8. Results. The incidence of adverse reactions of more than grade 3 was 22.5% in the S-1 group and 43.5% in the S-1/ CDDP group, and the treatment compliance was better in the S-1 group. The overall response rate was 25.9% in the S-1 group, and 36.8% in the S-1/CDDP group. The combination of S-1 with CDDP had better effects on the primary lesion and on differentiated-type carcinoma than S-1 alone. However, there was no difference in survival between the two patient groups. The median survival time after the initiation of treatment in the S-1 group was 322 days, and that in the S-1/CDDP group was 319 days. Conclusions. Our results suggest that the combination of CDDP with S-1 does not improve the long-term outcome of S-1 therapy.

本文言語英語
ページ(範囲)111-116
ページ数6
ジャーナルGastric Cancer
8
2
DOI
出版ステータス出版済み - 5 2005

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 消化器病学
  • 癌研究

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