Long-term outcomes of surgery for thymic carcinoma: Experience of 25 cases at a single institution

Tetsuzo Tagawa, Hidemi Suzuki, Takahiro Nakajima, Takekazu Iwata, Teruaki Mizobuchi, Shigetoshi Yoshida, Ichiro Yoshino

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)


Background Thymic carcinoma, a relatively rare entity, often presents as locally advanced disease, and sometimes as distant metastatic disease. The treatment strategy, long-term surgical outcomes and clinical prognostic factors have yet to be fully elucidated. Methods Clinical charts of 25 patients who underwent surgery for thymic carcinoma at our institution from 1991 to 2014 were retrospectively reviewed. Results The Masaoka stage was stage I in three patients (12%), II in eight (32%), III in four (16%), IVa in four (16%), and IVb in six (24%). Histologic subtypes were squamous cell carcinoma in 12 patients, well-differentiated neuroendocrine carcinoma in 5, undifferentiated carcinoma in 3, adenocarcinoma in 1, and others in 4. Three patients had paraneoplastic syndrome including myasthenia gravis, multiple endocrine neoplasia type 1 (MEN1), and Cushing syndrome. Neoadjuvant chemotherapy was administered to five patients (20%). Complete resection was achieved in 17 patients (68%). There were no perioperative deaths. Twelve patients received postoperative therapy. The 5- and 10-year overall survival rates were 76.2 and 63.5%, respectively. The 5- and 10-year survival rates of patients with Masaoka stage I-III were 88.9 and 74.1%, respectively, whereas the 5-year survival rate of stage IV was 50.0%. The 5- and 10-year survival rates of 17 patients who underwent complete resection were 88.9 and 71.1%, respectively. Of the 17 patients with complete resection, 3 patients experienced recurrence including lung and supraclavicular lymph node. Conclusion Even for this highly malignant disease, surgery could contribute to favorable long-term outcomes in the setting of multimodality therapy.

ジャーナルThoracic and Cardiovascular Surgeon
出版ステータス出版済み - 4月 1 2015

!!!All Science Journal Classification (ASJC) codes

  • 外科
  • 呼吸器内科
  • 循環器および心血管医学


「Long-term outcomes of surgery for thymic carcinoma: Experience of 25 cases at a single institution」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。