Long-term results of preoperative hyperthermo-chemo-radiotherapy (HCR) for patients with esophageal carcinoma invading neighboring structures (T4)

H. Kawaguchi, H. Saeki, K. Sonoda, T. Ohga, K. Kitamura, H. Nakashima, Y. Toh, H. Kuwano, K. Sugimachi

研究成果: Contribution to journalArticle査読

抄録

Patients: A total of 180 patients with esophageal carcinoma invading the neighboring structures (T4) were surgically treated by esophagectomy and reconstruction in the Department of Surgery II, Kyushu University from January 1965 to April 1997. Any of these cases with distant node metastasis and demonstrating organ metastasis or a combined resection of adjacent structures were excluded from this study. As a result, twenty-six patients treated with preoperative hyperthermo-chemo-radiotherapy (HCR Group), 39 treated either with preoperative radiotherapy or preoperative chemo- radiotherapy (R or CR Group) and 23 non-treated patients (Non-tx Group) were thus entered in this study. Results: The 3-year survival rates after esophagectomy in HCR Group, R or CR Group and Non-tx Group were 26.5%, 0% and 9%, respectively, while the 5-year survival rate of the HCR group was 15.9%. The group with preoperative HCR thus showed a significantly more favorable outcome than R or CR Group and Non-tx Group. (p <0.05). Discussion: The significant difference observed in the prognosis was thought to be due to the reinforced effect of local regulation due to hyperthermia. Our data thus suggest that preoperative HCR contributes to the prolonged post-operative survival for carcinoma of the esophagus invading the neighboring structures.

本文言語英語
ページ(範囲)1673-1676
ページ数4
ジャーナルJapanese Journal of Cancer and Chemotherapy
24
12
出版ステータス出版済み - 12 8 1997

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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