Long-term seizure outcome after resection surgery for temporal lobe epilepsy: Comparison between postoperative 2 and 7 years

Kimiaki Hashiguchi, Takato Morioka, Fumiaki Yoshida, Shinji Nagata, Tomio Sasaki, Yasushi Miyagi, Ayumi Sakata

研究成果: Contribution to journalArticle査読

抄録

Favorable short-term outcome is reported for the resective surgery in patients with temporal lobe epilepsy (TLE). However, few authors have demonstrated the long-term outcome up to the present. We evaluated the long-term seizure outcome of the patients after anterior temporal lobectomy with hippocampectomy for intractable TLE. Twenty seven patients who underwent the resection surgery between September 1994 and November 1999 and were followed up for more than 7 years after the surgery participated in this study. The outcome of the each patient was classified at the time of 2 and 7 years after the surgery, according to the Engel's classification. Among 13 cases with medial TLE which is associated with hippocampal sclerosis, 12 and 10 cases were classified into class I and IA, respectively at the time of postoperative 2 years. Meanwhile, 11 and 3 cases were classified into class I and IA at 7 years. Among 8 cases with lesional TLE, 6 and 4 cases were classified into class I and IA at the time of 2 years, which is the same 7 years later. In 6 cases with lateral TLE, 2 and 1 cases were classified into class I and IA both 2 and 7 years after the surgery. Antiepileptic drugs (AEDs) were completely discontinued in 4 cases (15%). In conclusion, although postoperative seizure outcome doesn't differ so much between 2 and 7 years after the surgery, the number of patients with complete seizure free (Engel's calss IA) falls off 7 years later, which were mostly due to the decrease or discontinuation of AEDs.

本文言語英語
ページ(範囲)65-73
ページ数9
ジャーナルJournal of the Japan Epilepsy Society
25
2
DOI
出版ステータス出版済み - 2007

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学

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