Long-term treatment with haloperidol decreases the mRNA levels of complexin I, but not complexin II, in rat prefrontal cortex, nucleus accumbens and ventral tegmental area

Tatsuo Nakahara, Keisuke Motomura, Kijiro Hashimoto, Hiroshi Ueki, Leo Gotoh, Hisao Hondo, Tetsuyuki Tsutsumi, Toshihide Kuroki, Makoto Hirano, Hideyuki Uchimura

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

抄録

The effect of long-term treatment with haloperidol on gene expression of the presynaptic protein complexins was investigated in the discrete brain regions of rats, using reverse transcription-polymerase chain reaction. Four-week-treatment with haloperidol decanoate (25 mg eq/kg) produced a significant decrease in the mRNA levels of complexin I in the medial prefrontal cortex, nucleus accumbens and ventral tegmental area, but not in the striatum and substantia nigra. No significant changes in complexin II mRNA levels were observed in any brain region examined here. The reduced expression of complexin I may be associated with the haloperidol-induced depolarization block of mesocorticolimbic dopamine neurons. Copyright (C) 2000 Elsevier Science Ireland Ltd.

元の言語英語
ページ(範囲)29-32
ページ数4
ジャーナルNeuroscience Letters
290
発行部数1
DOI
出版物ステータス出版済み - 8 18 2000

Fingerprint

Ventral Tegmental Area
Nucleus Accumbens
Haloperidol
Prefrontal Cortex
Messenger RNA
Dopaminergic Neurons
Brain
Substantia Nigra
Reverse Transcription
Gene Expression
Polymerase Chain Reaction
Proteins
complexin I
complexin II
haloperidol decanoate

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Long-term treatment with haloperidol decreases the mRNA levels of complexin I, but not complexin II, in rat prefrontal cortex, nucleus accumbens and ventral tegmental area. / Nakahara, Tatsuo; Motomura, Keisuke; Hashimoto, Kijiro; Ueki, Hiroshi; Gotoh, Leo; Hondo, Hisao; Tsutsumi, Tetsuyuki; Kuroki, Toshihide; Hirano, Makoto; Uchimura, Hideyuki.

:: Neuroscience Letters, 巻 290, 番号 1, 18.08.2000, p. 29-32.

研究成果: ジャーナルへの寄稿記事

Nakahara, Tatsuo ; Motomura, Keisuke ; Hashimoto, Kijiro ; Ueki, Hiroshi ; Gotoh, Leo ; Hondo, Hisao ; Tsutsumi, Tetsuyuki ; Kuroki, Toshihide ; Hirano, Makoto ; Uchimura, Hideyuki. / Long-term treatment with haloperidol decreases the mRNA levels of complexin I, but not complexin II, in rat prefrontal cortex, nucleus accumbens and ventral tegmental area. :: Neuroscience Letters. 2000 ; 巻 290, 番号 1. pp. 29-32.
@article{53a052d897c64ff3a5c2e8687a498b64,
title = "Long-term treatment with haloperidol decreases the mRNA levels of complexin I, but not complexin II, in rat prefrontal cortex, nucleus accumbens and ventral tegmental area",
abstract = "The effect of long-term treatment with haloperidol on gene expression of the presynaptic protein complexins was investigated in the discrete brain regions of rats, using reverse transcription-polymerase chain reaction. Four-week-treatment with haloperidol decanoate (25 mg eq/kg) produced a significant decrease in the mRNA levels of complexin I in the medial prefrontal cortex, nucleus accumbens and ventral tegmental area, but not in the striatum and substantia nigra. No significant changes in complexin II mRNA levels were observed in any brain region examined here. The reduced expression of complexin I may be associated with the haloperidol-induced depolarization block of mesocorticolimbic dopamine neurons. Copyright (C) 2000 Elsevier Science Ireland Ltd.",
author = "Tatsuo Nakahara and Keisuke Motomura and Kijiro Hashimoto and Hiroshi Ueki and Leo Gotoh and Hisao Hondo and Tetsuyuki Tsutsumi and Toshihide Kuroki and Makoto Hirano and Hideyuki Uchimura",
year = "2000",
month = "8",
day = "18",
doi = "10.1016/S0304-3940(00)01312-4",
language = "English",
volume = "290",
pages = "29--32",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Long-term treatment with haloperidol decreases the mRNA levels of complexin I, but not complexin II, in rat prefrontal cortex, nucleus accumbens and ventral tegmental area

AU - Nakahara, Tatsuo

AU - Motomura, Keisuke

AU - Hashimoto, Kijiro

AU - Ueki, Hiroshi

AU - Gotoh, Leo

AU - Hondo, Hisao

AU - Tsutsumi, Tetsuyuki

AU - Kuroki, Toshihide

AU - Hirano, Makoto

AU - Uchimura, Hideyuki

PY - 2000/8/18

Y1 - 2000/8/18

N2 - The effect of long-term treatment with haloperidol on gene expression of the presynaptic protein complexins was investigated in the discrete brain regions of rats, using reverse transcription-polymerase chain reaction. Four-week-treatment with haloperidol decanoate (25 mg eq/kg) produced a significant decrease in the mRNA levels of complexin I in the medial prefrontal cortex, nucleus accumbens and ventral tegmental area, but not in the striatum and substantia nigra. No significant changes in complexin II mRNA levels were observed in any brain region examined here. The reduced expression of complexin I may be associated with the haloperidol-induced depolarization block of mesocorticolimbic dopamine neurons. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - The effect of long-term treatment with haloperidol on gene expression of the presynaptic protein complexins was investigated in the discrete brain regions of rats, using reverse transcription-polymerase chain reaction. Four-week-treatment with haloperidol decanoate (25 mg eq/kg) produced a significant decrease in the mRNA levels of complexin I in the medial prefrontal cortex, nucleus accumbens and ventral tegmental area, but not in the striatum and substantia nigra. No significant changes in complexin II mRNA levels were observed in any brain region examined here. The reduced expression of complexin I may be associated with the haloperidol-induced depolarization block of mesocorticolimbic dopamine neurons. Copyright (C) 2000 Elsevier Science Ireland Ltd.

UR - http://www.scopus.com/inward/record.url?scp=0034683222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034683222&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(00)01312-4

DO - 10.1016/S0304-3940(00)01312-4

M3 - Article

C2 - 10925167

AN - SCOPUS:0034683222

VL - 290

SP - 29

EP - 32

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -