Long-term treatment with panitumumab monotherapy for recurrent colorectal cancer

Koji Ando, Eiji Oki, Hiroshi Saeki, Yuichiro Nakashima, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿 › 記事

抄録

With the development of new chemotherapy agents and methods, metastatic colorectal cancer patients can now achieve a survival time of >30 months. Higher line therapies have had a significant influence on the survival of these patients. However, it remains uncertain as to which therapy is the most effective and best tolerated. Herein, we describe the case of a patient with metastatic KRAS wild-type colorectal cancer who received panitumumab monotherapy as a third-line therapy after failure of 5-fluorouracil, irinotecan, oxaliplatin and bevacizumab. This patient had both lymph node and lung recurrence. The patient achieved a partial response time of 15 months. The lymph node and recurrent lung tumor had shrunk by 74 and 100 %, respectively, and the treatment was well tolerated with limited cutaneous toxicity. Panitumumab monotherapy may be an effective and well-tolerated treatment of KRAS wild-type metastatic colorectal cancer patients who have undergone many prior therapies. The present case showed a response to panitumumab monotherapy extending over a period of >1 year.
元の言語英語
ページ（範囲）151
ページ数154
ジャーナルInternational Cancer Conference Journal
巻4
発行部数3
出版物ステータス出版済み - 7 2015

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Colorectal Neoplasms
oxaliplatin
irinotecan
Therapeutics
Lymph Nodes
Lung
Survival
Fluorouracil
Reaction Time
panitumumab
Recurrence
Drug Therapy
Skin
Neoplasms

これを引用

Long-term treatment with panitumumab monotherapy for recurrent colorectal cancer. / Ando, Koji; Oki, Eiji; Saeki, Hiroshi; Nakashima, Yuichiro; Maehara, Yoshihiko.

：: International Cancer Conference Journal, 巻 4, 番号 3, 07.2015, p. 151.

研究成果: ジャーナルへの寄稿 › 記事

Ando, K, Oki, E, Saeki, H, Nakashima, Y & Maehara, Y 2015, 'Long-term treatment with panitumumab monotherapy for recurrent colorectal cancer', International Cancer Conference Journal, 巻. 4, 番号 3, pp. 151.
Ando K, Oki E, Saeki H, Nakashima Y, Maehara Y. Long-term treatment with panitumumab monotherapy for recurrent colorectal cancer. International Cancer Conference Journal. 2015 7;4(3):151.
Ando, Koji ; Oki, Eiji ; Saeki, Hiroshi ; Nakashima, Yuichiro ; Maehara, Yoshihiko. / Long-term treatment with panitumumab monotherapy for recurrent colorectal cancer. ：: International Cancer Conference Journal. 2015 ; 巻 4, 番号 3. pp. 151.
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abstract = "With the development of new chemotherapy agents and methods, metastatic colorectal cancer patients can now achieve a survival time of >30 months. Higher line therapies have had a significant influence on the survival of these patients. However, it remains uncertain as to which therapy is the most effective and best tolerated. Herein, we describe the case of a patient with metastatic KRAS wild-type colorectal cancer who received panitumumab monotherapy as a third-line therapy after failure of 5-fluorouracil, irinotecan, oxaliplatin and bevacizumab. This patient had both lymph node and lung recurrence. The patient achieved a partial response time of 15 months. The lymph node and recurrent lung tumor had shrunk by 74 and 100 {\%}, respectively, and the treatment was well tolerated with limited cutaneous toxicity. Panitumumab monotherapy may be an effective and well-tolerated treatment of KRAS wild-type metastatic colorectal cancer patients who have undergone many prior therapies. The present case showed a response to panitumumab monotherapy extending over a period of >1 year.",
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