Longitudinal changes in symptoms and plasma homovanillic acid levels in chronically medicated schizophrenic patients

Eiji Suzuki, Shigenobu Kanba, Masashi Nibuya, Sunao Adachi, Utako Sekiya, Futoshi Shintani, Norihasa Kinoshita, Gohei Yagi, Masahiro Asai

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)


A correlation has been noted between the changes in plasma homovanillic acid concentrations and changes in psychiatricy symptoms induced by neuroleptic treatment. Our objective was to determine whether plasma homovanillic acid concentration changed in accordance with the changes in symptoms over time. Twenty-eight chronically medicated schizophrenic inpatients received the same treatment regimen for 1 year. Symptoms and plasma homovanillic acid concentrations were examined every month and whenever conditions deteriorated. Plasma homovanillic acid concentrations were significantly higher in the patients in the worst condition than in the patients in the best condition. Further, when comparing the best and worst conditions of both the positive and negative symptoms, the change in psychiatric rating of positive and negative symptoms was correlated significantly with the change in plasma homovanillic acid level. These results suggest that a change in plasma homovanillic acid concentration can be produced not only by neuroleptic-induced dopaminergic blocking but also by a change in positive and negative symptoms of schizophrenia.

ジャーナルBiological Psychiatry
出版物ステータス出版済み - 11 15 1994


All Science Journal Classification (ASJC) codes

  • Biological Psychiatry