Loss of hIRH mRNA expression from premalignant adenomas and malignant cell lines

Nasim Ara Begum, Ahmet Coker, Kenji Shibuta, Richard S. Swanson, Lan Bo Chen, Masaki Mori, Graham F. Barnard

研究成果: ジャーナルへの寄稿学術誌査読

16 被引用数 (Scopus)

抄録

We recently isolated from differential displays and subsequently cloned a human α-intercrine (hIRH) whose mRNA is reduced in human hepatocellular carcinomas. We now report that on Northern blots its mRNA is absent from premalignant colonic adenomas and from all of 27 human malignant cell lines (including breast, cervix, colon, duodenal, gastric, leukemia, liver, lung, melanoma, and pancreatic lines). hIRH mRNA was present in most normal human and mouse tissues and fibroblast derived cell lines but absent from leukocytes and brain. Two mRNA signals, at ~ 2 Kb and ~ 3.5 Kb, had variation in signal strength or size between tissues and species.

本文言語英語
ページ(範囲)864-868
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
229
3
DOI
出版ステータス出版済み - 12月 24 1996
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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