Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan

Kazuyo Kurose, Masanori Terai, Nurtami Soedarsono, Doralina Rabello, Yumiko Nakajima, Robert D. Burk, Minoru Takagi

研究成果: ジャーナルへの寄稿記事

53 引用 (Scopus)

抄録

Objective To investigate the prevalence of human papillomavirus (HPV) infection in normal oral mucosa, and to observe the natural history in the oral cavity in oral swab samples collected from healthy volunteers on Miyako Island, Okinawa, Japan. Study design The prevalence of HPV infection in oral buccal mucosa cell scrapes collected between 2000 and 2002 from a cohort of 668 healthy volunteers was determined. HPV DNA was detected by consensus polymerase chain reaction (PCR) using MY09/MY11 primers followed by direct cycle sequencing. Just over 2 years later the HPV-positive participants were reevaluated. Results Of the 668 subjects, 662 samples were analyzed for HPV. HPV DNA was detected in 4 (0.6%) specimens. HPV type 16 (HPV16), HPV53, and HPV71, mucosal types, and HPV12, a cutaneous type, were all identified by direct sequencing. In the follow-up survey, the HPV71- and HPV12-positive participants again tested positive, while HPV DNA was not detected in the HPV16- and HPV53-positive participants. Conclusion The results of this study among healthy individuals from Miyako Island suggest that oral HPV infection is uncommon. In this cohort, HPV71 and HPV12 were persistent, while HPV16 and HPV53 were transient in normal oral mucosa.

元の言語英語
ページ(範囲)91-96
ページ数6
ジャーナルOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
98
発行部数1
DOI
出版物ステータス出版済み - 7 1 2004

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Papillomavirus Infections
Mouth Mucosa
Natural History
Islands
Volunteers
Japan
Human papillomavirus 16
DNA
Healthy Volunteers
Mouth
Polymerase Chain Reaction
Skin

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

これを引用

Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan. / Kurose, Kazuyo; Terai, Masanori; Soedarsono, Nurtami; Rabello, Doralina; Nakajima, Yumiko; Burk, Robert D.; Takagi, Minoru.

:: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 巻 98, 番号 1, 01.07.2004, p. 91-96.

研究成果: ジャーナルへの寄稿記事

Kurose, Kazuyo ; Terai, Masanori ; Soedarsono, Nurtami ; Rabello, Doralina ; Nakajima, Yumiko ; Burk, Robert D. ; Takagi, Minoru. / Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan. :: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2004 ; 巻 98, 番号 1. pp. 91-96.
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abstract = "Objective To investigate the prevalence of human papillomavirus (HPV) infection in normal oral mucosa, and to observe the natural history in the oral cavity in oral swab samples collected from healthy volunteers on Miyako Island, Okinawa, Japan. Study design The prevalence of HPV infection in oral buccal mucosa cell scrapes collected between 2000 and 2002 from a cohort of 668 healthy volunteers was determined. HPV DNA was detected by consensus polymerase chain reaction (PCR) using MY09/MY11 primers followed by direct cycle sequencing. Just over 2 years later the HPV-positive participants were reevaluated. Results Of the 668 subjects, 662 samples were analyzed for HPV. HPV DNA was detected in 4 (0.6{\%}) specimens. HPV type 16 (HPV16), HPV53, and HPV71, mucosal types, and HPV12, a cutaneous type, were all identified by direct sequencing. In the follow-up survey, the HPV71- and HPV12-positive participants again tested positive, while HPV DNA was not detected in the HPV16- and HPV53-positive participants. Conclusion The results of this study among healthy individuals from Miyako Island suggest that oral HPV infection is uncommon. In this cohort, HPV71 and HPV12 were persistent, while HPV16 and HPV53 were transient in normal oral mucosa.",
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AU - Burk, Robert D.

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N2 - Objective To investigate the prevalence of human papillomavirus (HPV) infection in normal oral mucosa, and to observe the natural history in the oral cavity in oral swab samples collected from healthy volunteers on Miyako Island, Okinawa, Japan. Study design The prevalence of HPV infection in oral buccal mucosa cell scrapes collected between 2000 and 2002 from a cohort of 668 healthy volunteers was determined. HPV DNA was detected by consensus polymerase chain reaction (PCR) using MY09/MY11 primers followed by direct cycle sequencing. Just over 2 years later the HPV-positive participants were reevaluated. Results Of the 668 subjects, 662 samples were analyzed for HPV. HPV DNA was detected in 4 (0.6%) specimens. HPV type 16 (HPV16), HPV53, and HPV71, mucosal types, and HPV12, a cutaneous type, were all identified by direct sequencing. In the follow-up survey, the HPV71- and HPV12-positive participants again tested positive, while HPV DNA was not detected in the HPV16- and HPV53-positive participants. Conclusion The results of this study among healthy individuals from Miyako Island suggest that oral HPV infection is uncommon. In this cohort, HPV71 and HPV12 were persistent, while HPV16 and HPV53 were transient in normal oral mucosa.

AB - Objective To investigate the prevalence of human papillomavirus (HPV) infection in normal oral mucosa, and to observe the natural history in the oral cavity in oral swab samples collected from healthy volunteers on Miyako Island, Okinawa, Japan. Study design The prevalence of HPV infection in oral buccal mucosa cell scrapes collected between 2000 and 2002 from a cohort of 668 healthy volunteers was determined. HPV DNA was detected by consensus polymerase chain reaction (PCR) using MY09/MY11 primers followed by direct cycle sequencing. Just over 2 years later the HPV-positive participants were reevaluated. Results Of the 668 subjects, 662 samples were analyzed for HPV. HPV DNA was detected in 4 (0.6%) specimens. HPV type 16 (HPV16), HPV53, and HPV71, mucosal types, and HPV12, a cutaneous type, were all identified by direct sequencing. In the follow-up survey, the HPV71- and HPV12-positive participants again tested positive, while HPV DNA was not detected in the HPV16- and HPV53-positive participants. Conclusion The results of this study among healthy individuals from Miyako Island suggest that oral HPV infection is uncommon. In this cohort, HPV71 and HPV12 were persistent, while HPV16 and HPV53 were transient in normal oral mucosa.

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