Lowered entrainment function in the suprachiasmatic nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) rats

Takao Shimazoe, Miyuki Maetani, Sachiko Nakamura, Shiro Yamanouchi, Shigenori Watanabe, Kyoko Miyasaka, Akira Kono, Akihiro Funakoshi

研究成果: Contribution to journalArticle

11 引用 (Scopus)

抜粋

The entrainment function in the suprachiasmatic nucleus (SCN) of young non-diabetic Otsuka Long Evans Tokushima Fatty (OLETF) rats was studied. OLETF rats significantly needed more days for re-entrainment to a new light-dark cycle than control Long Evans Tokushima Otsuka (LETO) rats. We also assessed Fos expression in the SCN induced by dim light exposure. The number of Fos-immunoreactive cells was significantly decreased in 5- to 13-week-old OLETF rats compared with LETO rats. Moreover, the effect of glutamate on neuronal activity in the SCN of OLETF rats were investigated. In young non-diabetic OLETF rats, the phase delay in the SCN neuronal firing rhythm induced by 1 μM glutamate was significantly less than that in LETO rats. These results suggested that the entrainment function is reduced in OLETF rats before the onset of diabetes.

元の言語英語
ページ(範囲)85-88
ページ数4
ジャーナルJapanese Journal of Pharmacology
80
発行部数1
DOI
出版物ステータス出版済み - 6 22 1999

All Science Journal Classification (ASJC) codes

  • Pharmacology

フィンガープリント Lowered entrainment function in the suprachiasmatic nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) rats' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Shimazoe, T., Maetani, M., Nakamura, S., Yamanouchi, S., Watanabe, S., Miyasaka, K., Kono, A., & Funakoshi, A. (1999). Lowered entrainment function in the suprachiasmatic nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) rats. Japanese Journal of Pharmacology, 80(1), 85-88. https://doi.org/10.1254/jjp.80.85