Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells

Yhiya M. Amen, Qinchang Zhu, Hai Bang Tran, Mohamed S. Afifi, Ahmed F. Halim, Ahmed Ashour, Amira Mira, Kuniyoshi Shimizu

研究成果: Contribution to journalArticle査読

20 被引用数 (Scopus)

抄録

A new oxygenated lanostane-type triterpene, named lucidumol C, together with six known compounds, was isolated from the chloroform extract of the fruiting bodies of Ganoderma lingzhi. Structures were established based on extensive spectroscopic and chemical studies. Potential cytotoxic activities of the isolated compounds were evaluated against human colorectal carcinoma (HCT-116, Caco-2), human liver carcinoma (HepG2), and human cervical carcinoma (HeLa) cell lines using WST-1 reagent. Selectivity was evaluated using normal human fibroblast cells (TIG-1 and HF19). Among the compounds, lucidumol C showed potent selective cytotoxicity against HCT-116 cells with an IC50 value of 7.86 ± 4.56 µM and selectivity index (SI) >10 with remarkable cytotoxic activities against Caco-2, HepG2 and HeLa cell lines.

本文言語英語
ページ(範囲)661-666
ページ数6
ジャーナルJournal of Natural Medicines
70
3
DOI
出版ステータス出版済み - 7 1 2016

All Science Journal Classification (ASJC) codes

  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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