Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)

Dedi Satria, Yhiya Amen, Yasuharu Niwa, Ahmed Ashour, Ahmed E. Allam, Kuniyoshi Shimizu

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

A new lanostane-type triterpenoid, lucidumol D (1) was isolated from the fruiting bodies of Ganoderma lingzhi. Its structure was elucidated on the basis of extensive 1D- and 2D-NMR studies as well as mass spectrometry. The cytotoxicity of lucidumol D against proliferation of several cancer cells were assayed by using MTT method and the obtained result suggested selective anti-proliferative and cytotoxic effects against MCF-7, HepG2, HeLa, Caco-2, and HCT-116. In comparison to lucidumol C (2) isolated previously by our group, the structure-activity relationship indicated that carbonyl function at C-11 is necessary to enhance the cytotoxicity.

本文言語英語
ページ(範囲)189-195
ページ数7
ジャーナルNatural Product Research
33
2
DOI
出版ステータス出版済み - 1 17 2019

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 生化学
  • 植物科学
  • 有機化学

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